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pubmed-article:11440372pubmed:abstractTextLamin A/C (LMNA) is located within a region on chromosome 1q that has been linked with Type II (non-insulin-dependent) diabetes mellitus in Pima Indians. Rare mutations in exon 8 of LMNA underlie Dunnigan-Type familial partial lipodystrophy, a disease characterized by regional adipocyte degeneration and frequently accompanied by insulin resistance, glucose intolerance, and diabetes. A more common variant in exon 10 (3408C/T) has recently been associated with obesity in non-diabetic aboriginal Canadian subjects. Because obesity is a strongly predisposing factor for Type II diabetes, we hypothesized that the LMNA 3408C/T variant could be associated with diabetes and body mass index in Pima Indians.lld:pubmed
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pubmed-article:11440372pubmed:articleTitleAnalysis of the lamin A/C gene as a candidate for type II diabetes susceptibility in Pima Indians.lld:pubmed
pubmed-article:11440372pubmed:affiliationPhoenix Epidemiology and Research Branch, National Institute of Diabetes and Kidney Diseases, National Institutes of Health, Phoenix, Arizona 85016, USA.lld:pubmed
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