| pubmed-article:11438479 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11438479 | lifeskim:mentions | umls-concept:C0076088 | lld:lifeskim |
| pubmed-article:11438479 | lifeskim:mentions | umls-concept:C0428791 | lld:lifeskim |
| pubmed-article:11438479 | lifeskim:mentions | umls-concept:C0172537 | lld:lifeskim |
| pubmed-article:11438479 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:11438479 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11438479 | pubmed:dateCreated | 2001-7-4 | lld:pubmed |
| pubmed-article:11438479 | pubmed:abstractText | We previously showed that the expression of tenascin (TN-C), an extracellular matrix glycoprotein found in developing bone and atherosclerotic plaque, and matrix metalloproteinase-2 (MMP-2) are coordinated and interdependent in cultured vascular smooth muscle cells. In this study, we hypothesized that TN-C and MMP-2 are mechanistically involved in the pathobiology of calcific aortic stenosis. Human calcific aortic stenosis cusps demonstrated immunohistochemically prominent deposition of TN-C, MMP-2, and alkaline phosphatase activity, as well as MMP-2 gelatinolytic activity. Although far lesser amounts of TN-C were noted in several of the grossly non-calcified valve cusps, MMP-2 and AP were never detected. Further, when aortic valve interstitial cells (both sheep and human) were cultivated on collagen supplemented with TN-C, both MMP-2 mRNA expression and MMP-2 gelatinolytic activity (both pro and active forms), were up-regulated compared to control. These observations support the view that accumulation of first TN-C and then MMP-2 are associated with progression of calcification. The residual presence of these proteins in severe calcifications is indicative of their involvement in the pathogenesis. | lld:pubmed |
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| pubmed-article:11438479 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11438479 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11438479 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11438479 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11438479 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:11438479 | pubmed:author | pubmed-author:LUEE | lld:pubmed |
| pubmed-article:11438479 | pubmed:author | pubmed-author:LevyR JRJ | lld:pubmed |
| pubmed-article:11438479 | pubmed:author | pubmed-author:SchoenF JFJ | lld:pubmed |
| pubmed-article:11438479 | pubmed:author | pubmed-author:JonesP LPL | lld:pubmed |
| pubmed-article:11438479 | pubmed:author | pubmed-author:MohlerE... | lld:pubmed |
| pubmed-article:11438479 | pubmed:author | pubmed-author:JianBB | lld:pubmed |
| pubmed-article:11438479 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11438479 | pubmed:volume | 159 | lld:pubmed |
| pubmed-article:11438479 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11438479 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11438479 | pubmed:pagination | 321-7 | lld:pubmed |
| pubmed-article:11438479 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11438479 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11438479 | pubmed:articleTitle | Matrix metalloproteinase-2 is associated with tenascin-C in calcific aortic stenosis. | lld:pubmed |
| pubmed-article:11438479 | pubmed:affiliation | Cardiology Research Laboratory, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania 19104-4318, USA. | lld:pubmed |
| pubmed-article:11438479 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11438479 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11438479 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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