| pubmed-article:11438459 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11438459 | lifeskim:mentions | umls-concept:C0036945 | lld:lifeskim |
| pubmed-article:11438459 | lifeskim:mentions | umls-concept:C0022646 | lld:lifeskim |
| pubmed-article:11438459 | lifeskim:mentions | umls-concept:C0041956 | lld:lifeskim |
| pubmed-article:11438459 | lifeskim:mentions | umls-concept:C0521457 | lld:lifeskim |
| pubmed-article:11438459 | lifeskim:mentions | umls-concept:C1510411 | lld:lifeskim |
| pubmed-article:11438459 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:11438459 | lifeskim:mentions | umls-concept:C1880287 | lld:lifeskim |
| pubmed-article:11438459 | lifeskim:mentions | umls-concept:C1517004 | lld:lifeskim |
| pubmed-article:11438459 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11438459 | pubmed:dateCreated | 2001-7-4 | lld:pubmed |
| pubmed-article:11438459 | pubmed:abstractText | Renal malformations are the commonest cause of chronic renal failure in children and they are often associated with urinary tract abnormalities that impair fetal urine flow. Up-regulation of transforming growth factor-beta1 (TGF-beta1) occurs after experimental postnatal urinary tract obstruction and we recently reported increased levels of TGF-beta1 in human renal malformations (Yang SP et al, Am J Pathol 2000, 157:1633-1647). These findings led us to propose that obstruction-induced stretch of developing renal epithelia causes up-regulation of TGF-beta1, which then perturbs renal development. In this study, therefore, we examined expression of components of the TGF-beta1 signaling axis in a previously characterized ovine model of fetal short-term urine flow impairment in which complete unilateral ureteric obstruction was induced at 90 days when a few layers of glomeruli had formed. Up-regulation of TGF-beta1 mRNA and protein was observed in obstructed kidneys, compared to sham-operated control organs, after only 10 days. Increased levels of TGF-beta1 receptors I (TGF-betaR1) and II (TGF-betaR2) were also detected on Western blot, and the cytokine and TGF-betaR1 co-localized in disrupted epithelia on immunohistochemistry. De novo expression of alpha-smooth muscle actin, a structural protein up-regulated during TGF-beta1-induced phenotypic switching between human renal dysplastic epithelial and mesenchymal lineages in vitro, was also observed in these aberrant epithelia. These findings implicate increased TGF-beta1 signaling in the early biological changes generated by fetal urinary tract obstruction. | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11438459 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11438459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438459 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11438459 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11438459 | pubmed:issn | 0002-9440 | lld:pubmed |
| pubmed-article:11438459 | pubmed:author | pubmed-author:WoolfA SAS | lld:pubmed |
| pubmed-article:11438459 | pubmed:author | pubmed-author:YangS PSP | lld:pubmed |
| pubmed-article:11438459 | pubmed:author | pubmed-author:QuintHH | lld:pubmed |
| pubmed-article:11438459 | pubmed:author | pubmed-author:WinyardP JPJ | lld:pubmed |
| pubmed-article:11438459 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11438459 | pubmed:volume | 159 | lld:pubmed |
| pubmed-article:11438459 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11438459 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11438459 | pubmed:pagination | 109-17 | lld:pubmed |
| pubmed-article:11438459 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:meshHeading | pubmed-meshheading:11438459... | lld:pubmed |
| pubmed-article:11438459 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11438459 | pubmed:articleTitle | Deregulation of renal transforming growth factor-beta1 after experimental short-term ureteric obstruction in fetal sheep. | lld:pubmed |
| pubmed-article:11438459 | pubmed:affiliation | Nephro-Urology Unit, Institute of Child Health, University College London, United Kingdom. | lld:pubmed |
| pubmed-article:11438459 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11438459 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11438459 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11438459 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11438459 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11438459 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11438459 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11438459 | lld:pubmed |
