| pubmed-article:11438168 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11438168 | lifeskim:mentions | umls-concept:C0927232 | lld:lifeskim |
| pubmed-article:11438168 | lifeskim:mentions | umls-concept:C0038585 | lld:lifeskim |
| pubmed-article:11438168 | lifeskim:mentions | umls-concept:C0205276 | lld:lifeskim |
| pubmed-article:11438168 | lifeskim:mentions | umls-concept:C0220839 | lld:lifeskim |
| pubmed-article:11438168 | lifeskim:mentions | umls-concept:C0439662 | lld:lifeskim |
| pubmed-article:11438168 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11438168 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11438168 | pubmed:dateCreated | 2001-7-4 | lld:pubmed |
| pubmed-article:11438168 | pubmed:abstractText | The response of parenchymal microglia to interferon-gamma (IFN-gamma) varies across the brain. To ask if local neurochemicals contribute to site-specific control, the influence of substance P (SP) and glutamate was evaluated in brainstem vs. hippocampus. In brainstem, stereotaxic injection of SP increased class II MHC upregulation by IFN-gamma, while a SP receptor antagonist (Spantide I) prevented it. In hippocampus, where the baseline response to IFN-gamma was lower, SP was ineffective, but blocking glutamate enhanced the response in a proportion of rats. Attempts to understand and control immune activity in the CNS should take the local neurochemical environment into account. | lld:pubmed |
| pubmed-article:11438168 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11438168 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438168 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11438168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11438168 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11438168 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11438168 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11438168 | pubmed:issn | 0165-5728 | lld:pubmed |
| pubmed-article:11438168 | pubmed:author | pubmed-author:LampsonL ALA | lld:pubmed |
| pubmed-article:11438168 | pubmed:author | pubmed-author:McCluskeyL... | lld:pubmed |
| pubmed-article:11438168 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11438168 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11438168 | pubmed:volume | 116 | lld:pubmed |
| pubmed-article:11438168 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11438168 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11438168 | pubmed:pagination | 136-46 | lld:pubmed |
| pubmed-article:11438168 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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| pubmed-article:11438168 | pubmed:meshHeading | pubmed-meshheading:11438168... | lld:pubmed |
| pubmed-article:11438168 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11438168 | pubmed:articleTitle | Local immune regulation in the central nervous system by substance P vs. glutamate. | lld:pubmed |
| pubmed-article:11438168 | pubmed:affiliation | Department of Neurosurgery, Brigham and Women's Hospital and Harvard Medical School, USA. lmccluskey@mail.mcg.edu | lld:pubmed |
| pubmed-article:11438168 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11438168 | pubmed:publicationType | Comparative Study | lld:pubmed |
| pubmed-article:11438168 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11438168 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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