| pubmed-article:11435074 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11435074 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11435074 | lifeskim:mentions | umls-concept:C0005684 | lld:lifeskim |
| pubmed-article:11435074 | lifeskim:mentions | umls-concept:C0242957 | lld:lifeskim |
| pubmed-article:11435074 | lifeskim:mentions | umls-concept:C1524119 | lld:lifeskim |
| pubmed-article:11435074 | lifeskim:mentions | umls-concept:C0334227 | lld:lifeskim |
| pubmed-article:11435074 | lifeskim:mentions | umls-concept:C1514559 | lld:lifeskim |
| pubmed-article:11435074 | lifeskim:mentions | umls-concept:C0022179 | lld:lifeskim |
| pubmed-article:11435074 | lifeskim:mentions | umls-concept:C0312418 | lld:lifeskim |
| pubmed-article:11435074 | lifeskim:mentions | umls-concept:C0036667 | lld:lifeskim |
| pubmed-article:11435074 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:11435074 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:11435074 | pubmed:dateCreated | 2001-7-3 | lld:pubmed |
| pubmed-article:11435074 | pubmed:abstractText | Soybean foods have been suggested to be practical chemopreventives for human urinary tract cancers. Recently, we demonstrated that the co-operative action of isoflavones results in an increased dose-dependent growth inhibition and apoptosis than any single isoflavone compound. This study aimed to examine the potential of HER-2/neu as a biological target for soy isoflavones. The sensitivity of the bladder cancer cell lines (n=7) to the isoflavones was inversely related to the amount of HER-2/neu expressed. By using HER-2/neu transfection experiments, all three stable transfectants showed a significant growth inhibition by the isoflavone mixture at concentrations attainable in normal adult urine. An increased inhibition of tyrosine phosphorylation of proteins immunoprecipitated by HER-2/Neu was observed in the neu-transfectants compared with controls. The results of this study suggest that HER-2/neu may be a practical biochemical target for urinary isoflavones in vivo. | lld:pubmed |
| pubmed-article:11435074 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11435074 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11435074 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11435074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11435074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11435074 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11435074 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11435074 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11435074 | pubmed:issn | 0959-8049 | lld:pubmed |
| pubmed-article:11435074 | pubmed:author | pubmed-author:ChowNN | lld:pubmed |
| pubmed-article:11435074 | pubmed:author | pubmed-author:LaiMM | lld:pubmed |
| pubmed-article:11435074 | pubmed:author | pubmed-author:TUPP | lld:pubmed |
| pubmed-article:11435074 | pubmed:author | pubmed-author:YehTT | lld:pubmed |
| pubmed-article:11435074 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11435074 | pubmed:volume | 37 | lld:pubmed |
| pubmed-article:11435074 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11435074 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11435074 | pubmed:pagination | 1413-8 | lld:pubmed |
| pubmed-article:11435074 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:meshHeading | pubmed-meshheading:11435074... | lld:pubmed |
| pubmed-article:11435074 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11435074 | pubmed:articleTitle | Overexpression of HER-2/neu enhances the sensitivity of human bladder cancer cells to urinary isoflavones. | lld:pubmed |
| pubmed-article:11435074 | pubmed:affiliation | Department of Medical Technology, Foo-Yin Institute of Technology, Kaohsiung, Republic of Taiwan, China. | lld:pubmed |
| pubmed-article:11435074 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11435074 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11435074 | lld:pubmed |
