| pubmed-article:11432868 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11432868 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11432868 | lifeskim:mentions | umls-concept:C0023796 | lld:lifeskim |
| pubmed-article:11432868 | lifeskim:mentions | umls-concept:C0023820 | lld:lifeskim |
| pubmed-article:11432868 | lifeskim:mentions | umls-concept:C0023821 | lld:lifeskim |
| pubmed-article:11432868 | lifeskim:mentions | umls-concept:C1254042 | lld:lifeskim |
| pubmed-article:11432868 | lifeskim:mentions | umls-concept:C0205224 | lld:lifeskim |
| pubmed-article:11432868 | pubmed:issue | 39 | lld:pubmed |
| pubmed-article:11432868 | pubmed:dateCreated | 2001-9-24 | lld:pubmed |
| pubmed-article:11432868 | pubmed:abstractText | Lipoprotein lipase (LPL) is the rate-limiting enzyme for the hydrolysis of triglycerides and the subsequent uptake of free fatty acids in extrahepatic tissues. Deficiency of LPL in humans (Type I hyperlipoproteinemia) is associated with massive chylomicronemia, low high density lipoprotein (HDL) cholesterol levels, and recurrent attacks of pancreatitis when not controlled by a strict diet. In contrast to humans, homozygous LPL knock-out mice (L0) do not survive suckling and die between 18 and 24 h after birth. In this study, an adenovirus-based protocol was utilized for the transient expression of LPL during the suckling period in an effort to rescue L0 mice. After a single intraperitoneal injection of 5x10(9) plaque-forming units of LPL-expressing virus immediately after birth, more than 90% of L0 mice survived the first days of life. 3% of L0 mice survived the entire suckling period and lived for up to 20 months, although LPL activity in mouse tissues and postheparin plasma was undetectable in all animals after 6 weeks of age. Adult LPL-deficient mice were smaller than their littermates until 2-3 months of age and exhibited very high triglyceride levels in the fed (4997 +/- 1102 versus 113.4 +/- 18.7 mg/dl) and fasted state (2007 +/- 375 versus 65.5 +/- 7.4 mg/dl). Plasma total cholesterol levels, free fatty acids, and ketone bodies were elevated in L0 mice, whereas plasma glucose was normal. Most strikingly, L0 mice lacked apoA-I-containing prebeta-HDL particles as well as mature HDL resulting in undetectable HDL cholesterol and HDL-apoA-I levels. HDL deficiency in plasma was evident despite normal apoA-I mRNA levels in the liver and normal apoA-I protein levels in plasma, which were predominantly found in the chylomicron fraction. The absence of prebeta-HDL and mature HDL particles supports the concept that the lipolysis of triglyceride-rich lipoproteins is an essential step for HDL maturation. | lld:pubmed |
| pubmed-article:11432868 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11432868 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11432868 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11432868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11432868 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11432868 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11432868 | pubmed:month | Sep | lld:pubmed |
| pubmed-article:11432868 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11432868 | pubmed:author | pubmed-author:FrankSS | lld:pubmed |
| pubmed-article:11432868 | pubmed:author | pubmed-author:KostnerG MGM | lld:pubmed |
| pubmed-article:11432868 | pubmed:author | pubmed-author:von... | lld:pubmed |
| pubmed-article:11432868 | pubmed:author | pubmed-author:KnippingGG | lld:pubmed |
| pubmed-article:11432868 | pubmed:author | pubmed-author:ZechnerRR | lld:pubmed |
| pubmed-article:11432868 | pubmed:author | pubmed-author:StraussJ GJG | lld:pubmed |
| pubmed-article:11432868 | pubmed:author | pubmed-author:HämmerleGG | lld:pubmed |
| pubmed-article:11432868 | pubmed:author | pubmed-author:KratkyDD | lld:pubmed |
| pubmed-article:11432868 | pubmed:author | pubmed-author:HrzenjakAA | lld:pubmed |
| pubmed-article:11432868 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11432868 | pubmed:day | 28 | lld:pubmed |
| pubmed-article:11432868 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11432868 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11432868 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11432868 | pubmed:pagination | 36083-90 | lld:pubmed |
| pubmed-article:11432868 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11432868 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11432868 | pubmed:articleTitle | Adenovirus-mediated rescue of lipoprotein lipase-deficient mice. Lipolysis of triglyceride-rich lipoproteins is essential for high density lipoprotein maturation in mice. | lld:pubmed |
| pubmed-article:11432868 | pubmed:affiliation | Institute of Molecular Biology, Biochemistry, and Microbiology, University of Graz, Graz A-8010, Austria. | lld:pubmed |
| pubmed-article:11432868 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11432868 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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