| pubmed-article:11431426 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11431426 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11431426 | lifeskim:mentions | umls-concept:C0229671 | lld:lifeskim |
| pubmed-article:11431426 | lifeskim:mentions | umls-concept:C0004561 | lld:lifeskim |
| pubmed-article:11431426 | lifeskim:mentions | umls-concept:C0011306 | lld:lifeskim |
| pubmed-article:11431426 | lifeskim:mentions | umls-concept:C1749467 | lld:lifeskim |
| pubmed-article:11431426 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:11431426 | lifeskim:mentions | umls-concept:C1413241 | lld:lifeskim |
| pubmed-article:11431426 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:11431426 | lifeskim:mentions | umls-concept:C0391871 | lld:lifeskim |
| pubmed-article:11431426 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11431426 | pubmed:issue | 7 | lld:pubmed |
| pubmed-article:11431426 | pubmed:dateCreated | 2001-6-29 | lld:pubmed |
| pubmed-article:11431426 | pubmed:abstractText | CD83 is an inducible glycoprotein expressed predominantly by dendritic cells (DC) and B lymphocytes. Expression of membrane CD83 (mCD83) is widely used as a marker of differentiated/activated DC but its function and ligand(s) are presently unknown. We report the existence of a soluble form of CD83 (sCD83). Using both a sCD83-specific ELISA and Western blotting, we could demonstrate the release of sCD83 by mCD83(+) B cell and Hodgkin's disease-derived cell lines, but not mCD83(-) cells. Inhibition of de novo protein synthesis did not affect the release of sCD83 during short-term (2 h) culture of cell lines although mCD83 expression was significantly reduced, suggesting sCD83 is generated by the release of mCD83. Isolated tonsillar B lymphocytes and monocyte-derived DC, which are mCD83(low), released only low levels of sCD83 during culture. However, the differentiation/activation of these populations both up-regulated mCD83 and increased sCD83 release significantly. Analysis of sera from normal donors demonstrated the presence of low levels (121 +/- 3.6 pg/ml) of circulating sCD83. Further studies utilizing purified sCD83 and the analysis of sCD83 levels in disease may provide clues to the function and ligand(s) of CD83. | lld:pubmed |
| pubmed-article:11431426 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11431426 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11431426 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11431426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11431426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11431426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11431426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11431426 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11431426 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11431426 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11431426 | pubmed:issn | 0953-8178 | lld:pubmed |
| pubmed-article:11431426 | pubmed:author | pubmed-author:KatoMM | lld:pubmed |
| pubmed-article:11431426 | pubmed:author | pubmed-author:McKenzieJ LJL | lld:pubmed |
| pubmed-article:11431426 | pubmed:author | pubmed-author:HartD NDN | lld:pubmed |
| pubmed-article:11431426 | pubmed:author | pubmed-author:HockB DBD | lld:pubmed |
| pubmed-article:11431426 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11431426 | pubmed:volume | 13 | lld:pubmed |
| pubmed-article:11431426 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11431426 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11431426 | pubmed:pagination | 959-67 | lld:pubmed |
| pubmed-article:11431426 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:11431426 | pubmed:meshHeading | pubmed-meshheading:11431426... | lld:pubmed |
| pubmed-article:11431426 | pubmed:meshHeading | pubmed-meshheading:11431426... | lld:pubmed |
| pubmed-article:11431426 | pubmed:meshHeading | pubmed-meshheading:11431426... | lld:pubmed |
| pubmed-article:11431426 | pubmed:meshHeading | pubmed-meshheading:11431426... | lld:pubmed |
| pubmed-article:11431426 | pubmed:meshHeading | pubmed-meshheading:11431426... | lld:pubmed |
| pubmed-article:11431426 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11431426 | pubmed:articleTitle | A soluble form of CD83 is released from activated dendritic cells and B lymphocytes, and is detectable in normal human sera. | lld:pubmed |
| pubmed-article:11431426 | pubmed:affiliation | Haematology/Immunology Research Group, Christchurch Hospital and Christchurch School of Medicine, Christchurch, New Zealand. | lld:pubmed |
| pubmed-article:11431426 | pubmed:publicationType | Journal Article | lld:pubmed |
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