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pubmed-article:11429881pubmed:abstractText[figure: see text] A new methodology for the synthesis of substituted alkynes is described. In the presence of copper(I) thiophene-2-carboxylate (CuTC) or copper (I) 3-methylsalicylate (CuMeSal), the palladium-catalyzed cross-coupling of thioalkyne derivatives with boronic acids affords functionalized alkynes in yields ranging from 39 to 91%. This coupling occurs efficiently under mild, nonbasic conditions with a wide variety of thioalkynes and boronic acids, providing a reaction complementary to the Sonogashira protocol.lld:pubmed
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pubmed-article:11429881pubmed:articleTitleSubstituted alkyne synthesis under nonbasic conditions: copper carboxylate-mediated, palladium-catalyzed thioalkyne-boronic acid cross-coupling.lld:pubmed
pubmed-article:11429881pubmed:affiliationDepartment of Chemistry, Emory University, 1515 Pierce Drive, Atlanta, Georgia 30322, USA.lld:pubmed
pubmed-article:11429881pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11429881pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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