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pubmed-article:11429866pubmed:abstractText[figure: see text] The halohydrin dehalogenase from Agrobacterium radiobacter AD1 catalyzed the highly enantioselective and beta-regioselective azidolysis of (substituted) styrene oxides. By means of kinetic resolutions the remaining epoxide and the formed azido alcohol could be obtained in very high ee. In a large scale conversion, the decrease in yield and selectivity due to the uncatalyzed chemical side reaction could be overcome by slow addition of azide.lld:pubmed
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pubmed-article:11429866pubmed:articleTitleHighly enantioselective and regioselective biocatalytic azidolysis of aromatic epoxides.lld:pubmed
pubmed-article:11429866pubmed:affiliationDepartment of Biochemistry, Groningen Biomolecular Sciences and Biotechnology Institute, and Department of Organic and Molecular Inorganic Chemistry, University of Groningen, Nijenborgh 4, 9747 AG Groningen, The Netherlands.lld:pubmed
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