| pubmed-article:11410717 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11410717 | lifeskim:mentions | umls-concept:C2349001 | lld:lifeskim |
| pubmed-article:11410717 | lifeskim:mentions | umls-concept:C0681850 | lld:lifeskim |
| pubmed-article:11410717 | lifeskim:mentions | umls-concept:C1706203 | lld:lifeskim |
| pubmed-article:11410717 | lifeskim:mentions | umls-concept:C2697811 | lld:lifeskim |
| pubmed-article:11410717 | lifeskim:mentions | umls-concept:C0000966 | lld:lifeskim |
| pubmed-article:11410717 | lifeskim:mentions | umls-concept:C0048504 | lld:lifeskim |
| pubmed-article:11410717 | lifeskim:mentions | umls-concept:C0205307 | lld:lifeskim |
| pubmed-article:11410717 | lifeskim:mentions | umls-concept:C0441889 | lld:lifeskim |
| pubmed-article:11410717 | lifeskim:mentions | umls-concept:C1412335 | lld:lifeskim |
| pubmed-article:11410717 | lifeskim:mentions | umls-concept:C1550501 | lld:lifeskim |
| pubmed-article:11410717 | lifeskim:mentions | umls-concept:C0547047 | lld:lifeskim |
| pubmed-article:11410717 | lifeskim:mentions | umls-concept:C0442040 | lld:lifeskim |
| pubmed-article:11410717 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11410717 | pubmed:dateCreated | 2001-6-18 | lld:pubmed |
| pubmed-article:11410717 | pubmed:abstractText | Carcinogenic acetaldehyde is produced from ethanol locally in the upper digestive tract via alcohol dehydrogenases (ADHs) of oral microbes, mucosal cells, and salivary glands. Acetaldehyde is further oxidized into less harmful acetate mainly by the aldehyde dehydrogenase-2 (ALDH2) enzyme. ALDH2-deficiency increases salivary acetaldehyde levels and the risk for upper digestive tract cancer in heavy alcohol drinkers. 4-methylpyrazole (4-MP) is an ADH-inhibitor which could reduce the local production of acetaldehyde from ethanol in the saliva. | lld:pubmed |
| pubmed-article:11410717 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11410717 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11410717 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11410717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11410717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11410717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11410717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11410717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11410717 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11410717 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11410717 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11410717 | pubmed:issn | 0145-6008 | lld:pubmed |
| pubmed-article:11410717 | pubmed:author | pubmed-author:SalaspuroMM | lld:pubmed |
| pubmed-article:11410717 | pubmed:author | pubmed-author:VäkeväinenSS | lld:pubmed |
| pubmed-article:11410717 | pubmed:author | pubmed-author:TillonenJJ | lld:pubmed |
| pubmed-article:11410717 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11410717 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:11410717 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11410717 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11410717 | pubmed:pagination | 829-34 | lld:pubmed |
| pubmed-article:11410717 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
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| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
| pubmed-article:11410717 | pubmed:meshHeading | pubmed-meshheading:11410717... | lld:pubmed |
| pubmed-article:11410717 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11410717 | pubmed:articleTitle | 4-Methylpyrazole decreases salivary acetaldehyde levels in aldh2-deficient subjects but not in subjects with normal aldh2. | lld:pubmed |
| pubmed-article:11410717 | pubmed:affiliation | Research Unit of Alcohol Diseases, Helsinki University Central Hospital, Helsinki, Finland. | lld:pubmed |
| pubmed-article:11410717 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11410717 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11410717 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11410717 | lld:pubmed |
