| pubmed-article:11403209 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11403209 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11403209 | lifeskim:mentions | umls-concept:C0026844 | lld:lifeskim |
| pubmed-article:11403209 | lifeskim:mentions | umls-concept:C1135918 | lld:lifeskim |
| pubmed-article:11403209 | lifeskim:mentions | umls-concept:C0282554 | lld:lifeskim |
| pubmed-article:11403209 | lifeskim:mentions | umls-concept:C0019878 | lld:lifeskim |
| pubmed-article:11403209 | lifeskim:mentions | umls-concept:C1563937 | lld:lifeskim |
| pubmed-article:11403209 | lifeskim:mentions | umls-concept:C0017262 | lld:lifeskim |
| pubmed-article:11403209 | lifeskim:mentions | umls-concept:C2911684 | lld:lifeskim |
| pubmed-article:11403209 | lifeskim:mentions | umls-concept:C0185117 | lld:lifeskim |
| pubmed-article:11403209 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11403209 | pubmed:dateCreated | 2001-6-13 | lld:pubmed |
| pubmed-article:11403209 | pubmed:abstractText | Hyperhomocysteinemia is an independent risk factor for atherosclerosis and atherothrombosis. While in vitro studies have revealed a number of homocysteine-mediated alterations in the thromboregulatory properties of endothelial cells, comparatively little is known about homocysteine-modulated smooth muscle cell function. We observed that exposure of human aortic smooth muscle cells to pathophysiologically relevant concentrations of homocysteine results in concentration-dependent increases in cytokine-induced MCP-1 and IL-8 secretion. RNase protection assays revealed that both MCP-1 and IL-8 mRNA concentrations are increased in homocysteine-treated smooth muscle cells when compared to cells activated with cytokines alone. Homocysteine treatment also increased cytosolic-to-nuclear translocation of the p65 and p50 subunits of the Rel/NF-kappaB family of transcription factors but had no effect on AP-1 activation. Cumulatively, these data suggest that homocysteine may increase monocyte recruitment into developing atherosclerotic lesions by upregulating MCP-1 and IL-8 expression in vascular smooth muscle cells. | lld:pubmed |
| pubmed-article:11403209 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11403209 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11403209 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11403209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11403209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11403209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11403209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11403209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11403209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11403209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11403209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11403209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11403209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11403209 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11403209 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11403209 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11403209 | pubmed:issn | 0360-3997 | lld:pubmed |
| pubmed-article:11403209 | pubmed:author | pubmed-author:DesaiAA | lld:pubmed |
| pubmed-article:11403209 | pubmed:author | pubmed-author:WarrenJ SJS | lld:pubmed |
| pubmed-article:11403209 | pubmed:author | pubmed-author:LankfordH AHA | lld:pubmed |
| pubmed-article:11403209 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11403209 | pubmed:volume | 25 | lld:pubmed |
| pubmed-article:11403209 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11403209 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11403209 | pubmed:pagination | 179-86 | lld:pubmed |
| pubmed-article:11403209 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
| pubmed-article:11403209 | pubmed:meshHeading | pubmed-meshheading:11403209... | lld:pubmed |
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| pubmed-article:11403209 | pubmed:meshHeading | pubmed-meshheading:11403209... | lld:pubmed |
| pubmed-article:11403209 | pubmed:meshHeading | pubmed-meshheading:11403209... | lld:pubmed |
| pubmed-article:11403209 | pubmed:meshHeading | pubmed-meshheading:11403209... | lld:pubmed |
| pubmed-article:11403209 | pubmed:meshHeading | pubmed-meshheading:11403209... | lld:pubmed |
| pubmed-article:11403209 | pubmed:meshHeading | pubmed-meshheading:11403209... | lld:pubmed |
| pubmed-article:11403209 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11403209 | pubmed:articleTitle | Homocysteine augments cytokine-induced chemokine expression in human vascular smooth muscle cells: implications for atherogenesis. | lld:pubmed |
| pubmed-article:11403209 | pubmed:affiliation | Department of Pathology, University of Michigan Medical School, Ann Arbor 48109-0602, USA. | lld:pubmed |
| pubmed-article:11403209 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11403209 | lld:pubmed |
