| pubmed-article:11399672 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11399672 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11399672 | lifeskim:mentions | umls-concept:C0134835 | lld:lifeskim |
| pubmed-article:11399672 | lifeskim:mentions | umls-concept:C0312860 | lld:lifeskim |
| pubmed-article:11399672 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:11399672 | lifeskim:mentions | umls-concept:C1515655 | lld:lifeskim |
| pubmed-article:11399672 | lifeskim:mentions | umls-concept:C1527180 | lld:lifeskim |
| pubmed-article:11399672 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11399672 | pubmed:dateCreated | 2001-6-11 | lld:pubmed |
| pubmed-article:11399672 | pubmed:abstractText | The role of selectins in neutrophil emigration in response to the CXC chemokines KC and MIP-2 was investigated in wild type and P-selectin deficient mice. Intrapleural injection of KC or MIP-2 induced a rapid and specific neutrophil accumulation. Emigration 2 h after KC or MIP-2 was reduced 83 - 88% by anti-L-selectin mAb and 53 - 63% by anti-P-selectin mAb. Co-administration of anti-L- and P-selectin mAbs abolished neutrophil migration induced by either chemokine. An anti-E-selectin mAb tested alone did not affect KC-induced neutrophil migration after 2 or 4 h. Moreover, anti-E-selectin did not have an additive inhibitory effect on KC-induced neutrophil migration compared with P-selectin blockade alone. This was found when neutrophil migration was measured at 2 and 4 h after KC. Despite a blood neutrophilia, neutrophil migration at 2 and 4 h after KC was markedly smaller (by approximately 90%) in P-selectin deficient mice compared with wild type animals. Responses at both time points were not decreased further in animals given E-selectin mAb but were reduced to the PBS control level in the presence of anti-L-selectin. In vitro study of cultured murine endothelial cells demonstrated that KC can directly increase cell surface P-selectin expression. These data suggest that CXC chemokine-induced neutrophil accumulation is dependent on both neutrophil L-selectin and a rapid upregulation of endothelial P-selectin but there is no evidence for E-selectin induction. | lld:pubmed |
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| pubmed-article:11399672 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11399672 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11399672 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11399672 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11399672 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:11399672 | pubmed:author | pubmed-author:HellewellP... | lld:pubmed |
| pubmed-article:11399672 | pubmed:author | pubmed-author:MiotlaJ MJM | lld:pubmed |
| pubmed-article:11399672 | pubmed:author | pubmed-author:RidgerV CVC | lld:pubmed |
| pubmed-article:11399672 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11399672 | pubmed:volume | 133 | lld:pubmed |
| pubmed-article:11399672 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11399672 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11399672 | pubmed:pagination | 550-6 | lld:pubmed |
| pubmed-article:11399672 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11399672 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11399672 | pubmed:articleTitle | Dominant role of L- and P-selectin in mediating CXC chemokine-induced neutrophil migration in vivo. | lld:pubmed |
| pubmed-article:11399672 | pubmed:affiliation | Endothelial Cell Biology Laboratory, Imperial Cancer Research Fund, Lincoln's Inn Fields, London WC2A 3PX. | lld:pubmed |
| pubmed-article:11399672 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11399672 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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