| pubmed-article:11390600 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C1622968 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C1332717 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C1706438 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C0085358 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C0029005 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C0669391 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C0013081 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C1413244 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C2698600 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C0086860 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:11390600 | lifeskim:mentions | umls-concept:C0750540 | lld:lifeskim |
| pubmed-article:11390600 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:11390600 | pubmed:dateCreated | 2001-6-6 | lld:pubmed |
| pubmed-article:11390600 | pubmed:abstractText | The E7 oncoprotein of human papillomavirus 16 (HPV16) transforms basal and suprabasal cervical epithelial cells and is a tumor-specific antigen in cervical carcinoma, to which immunotherapeutic strategies aimed at cytotoxic T-lymphocyte (CTL) induction are currently directed. By quantifying major histocompatibility complex class I tetramer-binding T cells and CTL in mice expressing an HPV16 E7 transgene from the keratin-14 (K14) promoter in basal and suprabasal keratinocytes and in thymic cortical epithelium, we show that antigen responsiveness of both E7- and non-E7-specific CD8+ cells is down-regulated compared to non-E7 transgenic control mice. We show that the effect is specific for E7, and not another transgene, expressed from the K14 promoter. Down-regulation did not involve deletion of CD8+ T cells of high affinity or high avidity, and T-cell receptor (TCR) Vbeta-chain usage and TCR receptor density were similar in antigen-responsive cells from E7 transgenic and non-E7 transgenic mice. These data indicate that E7 expressed chronically from the K14 promoter nonspecifically down-regulates CD8+ T-cell responses. The in vitro data correlated with the failure of immunized E7 transgenic mice to control the growth of an E7-expressing tumor challenge. We have previously shown that E7-directed CTL down-regulation correlates with E7 expression in peripheral but not thymic epithelium (T. Doan et al., J. Virol. 73:6166-6170, 1999). The findings have implications for the immunological consequences of E7-expressing tumor development and E7-directed immunization strategies. Generically, the findings illustrate a T-cell immunomodulatory function for a virally encoded human oncoprotein. | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11390600 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11390600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390600 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11390600 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11390600 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:11390600 | pubmed:author | pubmed-author:LambertPP | lld:pubmed |
| pubmed-article:11390600 | pubmed:author | pubmed-author:BrysonGG | lld:pubmed |
| pubmed-article:11390600 | pubmed:author | pubmed-author:StreetMM | lld:pubmed |
| pubmed-article:11390600 | pubmed:author | pubmed-author:TindleR WRW | lld:pubmed |
| pubmed-article:11390600 | pubmed:author | pubmed-author:FrazerI HIH | lld:pubmed |
| pubmed-article:11390600 | pubmed:author | pubmed-author:LeggattG RGR | lld:pubmed |
| pubmed-article:11390600 | pubmed:author | pubmed-author:DoanTT | lld:pubmed |
| pubmed-article:11390600 | pubmed:author | pubmed-author:HerdKK | lld:pubmed |
| pubmed-article:11390600 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11390600 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:11390600 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11390600 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11390600 | pubmed:pagination | 5985-97 | lld:pubmed |
| pubmed-article:11390600 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
| pubmed-article:11390600 | pubmed:meshHeading | pubmed-meshheading:11390600... | lld:pubmed |
| pubmed-article:11390600 | pubmed:meshHeading | pubmed-meshheading:11390600... | lld:pubmed |
| pubmed-article:11390600 | pubmed:meshHeading | pubmed-meshheading:11390600... | lld:pubmed |
| pubmed-article:11390600 | pubmed:meshHeading | pubmed-meshheading:11390600... | lld:pubmed |
| pubmed-article:11390600 | pubmed:meshHeading | pubmed-meshheading:11390600... | lld:pubmed |
| pubmed-article:11390600 | pubmed:meshHeading | pubmed-meshheading:11390600... | lld:pubmed |
| pubmed-article:11390600 | pubmed:meshHeading | pubmed-meshheading:11390600... | lld:pubmed |
