| pubmed-article:11390595 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11390595 | lifeskim:mentions | umls-concept:C0042776 | lld:lifeskim |
| pubmed-article:11390595 | lifeskim:mentions | umls-concept:C0024299 | lld:lifeskim |
| pubmed-article:11390595 | lifeskim:mentions | umls-concept:C0023492 | lld:lifeskim |
| pubmed-article:11390595 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11390595 | lifeskim:mentions | umls-concept:C0332307 | lld:lifeskim |
| pubmed-article:11390595 | lifeskim:mentions | umls-concept:C0036055 | lld:lifeskim |
| pubmed-article:11390595 | lifeskim:mentions | umls-concept:C0999517 | lld:lifeskim |
| pubmed-article:11390595 | lifeskim:mentions | umls-concept:C0376613 | lld:lifeskim |
| pubmed-article:11390595 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:11390595 | pubmed:dateCreated | 2001-6-6 | lld:pubmed |
| pubmed-article:11390595 | pubmed:abstractText | We assessed the immunogenicities and efficacies of two highly attenuated vaccinia virus-derived NYVAC vaccine candidates encoding the human T-cell leukemia/lymphoma virus type 1 (HTLV-1) env gene or both the env and gag genes in prime-boost pilot regimens in combination with naked DNA expressing the HTLV-1 envelope. Three inoculations of NYVAC HTLV-1 env at 0, 1, and 3 months followed by a single inoculation of DNA env at 9 months protected against intravenous challenge with HTLV-1-infected cells in one of three immunized squirrel monkeys. Furthermore, humoral and cell-mediated immune responses against HTLV-1 Env could be detected in this protected animal. However, priming the animal with a single dose of env DNA, followed by immunization with the NYVAC HTLV-1 gag and env vaccine at 6, 7, and 8 months, protected all three animals against challenge with HTLV-1-infected cells. With this protocol, antibodies against HTLV-1 Env and cell-mediated responses against Env and Gag could also be detected in the protected animals. Although the relative superiority of a DNA prime-NYVAC boost regimen over addition of the Gag component as an immunogen cannot be assessed directly, our findings nevertheless show that an HTLV-1 vaccine approach is feasible and deserves further study. | lld:pubmed |
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| pubmed-article:11390595 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11390595 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390595 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11390595 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11390595 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11390595 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:11390595 | pubmed:author | pubmed-author:de ThéGG | lld:pubmed |
| pubmed-article:11390595 | pubmed:author | pubmed-author:FranchiniGG | lld:pubmed |
| pubmed-article:11390595 | pubmed:author | pubmed-author:GessainAA | lld:pubmed |
| pubmed-article:11390595 | pubmed:author | pubmed-author:TartagliaJJ | lld:pubmed |
| pubmed-article:11390595 | pubmed:author | pubmed-author:KazanjiMM | lld:pubmed |
| pubmed-article:11390595 | pubmed:author | pubmed-author:TalarminAA | lld:pubmed |
| pubmed-article:11390595 | pubmed:author | pubmed-author:ContaminHH | lld:pubmed |
| pubmed-article:11390595 | pubmed:author | pubmed-author:de ThoisyBB | lld:pubmed |
| pubmed-article:11390595 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11390595 | pubmed:volume | 75 | lld:pubmed |
| pubmed-article:11390595 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11390595 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11390595 | pubmed:pagination | 5939-48 | lld:pubmed |
| pubmed-article:11390595 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11390595 | pubmed:meshHeading | pubmed-meshheading:11390595... | lld:pubmed |
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| pubmed-article:11390595 | pubmed:meshHeading | pubmed-meshheading:11390595... | lld:pubmed |
| pubmed-article:11390595 | pubmed:meshHeading | pubmed-meshheading:11390595... | lld:pubmed |
| pubmed-article:11390595 | pubmed:meshHeading | pubmed-meshheading:11390595... | lld:pubmed |
| pubmed-article:11390595 | pubmed:meshHeading | pubmed-meshheading:11390595... | lld:pubmed |
| pubmed-article:11390595 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11390595 | pubmed:articleTitle | Immunogenicity and protective efficacy of recombinant human T-cell leukemia/lymphoma virus type 1 NYVAC and naked DNA vaccine candidates in squirrel monkeys (Saimiri sciureus). | lld:pubmed |
| pubmed-article:11390595 | pubmed:affiliation | Laboratoire de Rétrovirologie, Institut Pasteur de la Guyane, 23 Av. Pasteur, Cayenne, French Guiana. mkazanji@pasteur-cayenne.fr | lld:pubmed |
| pubmed-article:11390595 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11390595 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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