| pubmed-article:11390582 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11390582 | lifeskim:mentions | umls-concept:C0019704 | lld:lifeskim |
| pubmed-article:11390582 | lifeskim:mentions | umls-concept:C0039194 | lld:lifeskim |
| pubmed-article:11390582 | lifeskim:mentions | umls-concept:C0024432 | lld:lifeskim |
| pubmed-article:11390582 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:11390582 | lifeskim:mentions | umls-concept:C0033268 | lld:lifeskim |
| pubmed-article:11390582 | lifeskim:mentions | umls-concept:C0205263 | lld:lifeskim |
| pubmed-article:11390582 | pubmed:issue | 13 | lld:pubmed |
| pubmed-article:11390582 | pubmed:dateCreated | 2001-6-6 | lld:pubmed |
| pubmed-article:11390582 | pubmed:abstractText | We examined the early effects of infection by CCR5-using (R5 human immunodeficiency virus [HIV]) and CXCR4-using (X4 HIV) strains of HIV type 1 (HIV-1) on chemokine production by primary human monocyte-derived macrophages (MDM). While R5 HIV, but not X4 HIV, replicated in MDM, we found that the production of the C-X-C chemokine growth-regulated oncogene alpha (GRO-alpha) was markedly stimulated by X4 HIV and, to a much lesser extent, by R5 HIV. HIV-1 gp120 engagement of CXCR4 initiated the stimulation of GRO-alpha production, an effect blocked by antibodies to CXCR4. GRO-alpha then fed back and stimulated HIV-1 replication in both MDM and lymphocytes, and antibodies that neutralize GRO-alpha or CXCR2 (the receptor for GRO-alpha) markedly reduced viral replication in MDM and peripheral blood mononuclear cells. Therefore, activation of MDM by HIV-1 gp120 engagement of CXCR4 initiates an autocrine-paracrine loop that may be important in disease progression after the emergence of X4 HIV. | lld:pubmed |
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| pubmed-article:11390582 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11390582 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11390582 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11390582 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11390582 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11390582 | pubmed:month | Jul | lld:pubmed |
| pubmed-article:11390582 | pubmed:issn | 0022-538X | lld:pubmed |
| pubmed-article:11390582 | pubmed:author | pubmed-author:StrieterR MRM | lld:pubmed |
| pubmed-article:11390582 | pubmed:author | pubmed-author:MarkovitzD... | lld:pubmed |
| pubmed-article:11390582 | pubmed:author | pubmed-author:CoffeyM JMJ | lld:pubmed |
| pubmed-article:11390582 | pubmed:author | pubmed-author:LangB TBT | lld:pubmed |
| pubmed-article:11390582 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11390582 | pubmed:volume | 75 | lld:pubmed |
