| pubmed-article:11389192 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11389192 | lifeskim:mentions | umls-concept:C0007786 | lld:lifeskim |
| pubmed-article:11389192 | lifeskim:mentions | umls-concept:C0058980 | lld:lifeskim |
| pubmed-article:11389192 | lifeskim:mentions | umls-concept:C1414326 | lld:lifeskim |
| pubmed-article:11389192 | lifeskim:mentions | umls-concept:C0035124 | lld:lifeskim |
| pubmed-article:11389192 | lifeskim:mentions | umls-concept:C1515877 | lld:lifeskim |
| pubmed-article:11389192 | lifeskim:mentions | umls-concept:C0683783 | lld:lifeskim |
| pubmed-article:11389192 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11389192 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11389192 | pubmed:dateCreated | 2001-6-4 | lld:pubmed |
| pubmed-article:11389192 | pubmed:abstractText | Reperfusion after global brain ischemia results initially in a widespread suppression of protein synthesis in neurons, which persists in vulnerable neurons, that is caused by the inhibition of translation initiation as a result of the phosphorylation of the alpha-subunit of eukaryotic initiation factor 2 (eIF2alpha). To identify kinases responsible for eIF2alpha phosphorylation [eIF2alpha(P)] during brain reperfusion, we induced ischemia by bilateral carotid artery occlusion followed by post-ischemic assessment of brain eIF2alpha(P) in mice with homozygous functional knockouts in the genes encoding the heme-regulated eIF2alpha kinase (HRI), or the amino acid-regulated eIF2alpha kinase (GCN2). A 10-fold increase in eIF2alpha(P) was observed in reperfused wild-type mice and in the HRI-/- or GCN2-/- mice. However, in all reperfused groups, the RNA-dependent protein kinase (PKR)-like endoplasmic reticulum eIF2alpha kinase (PERK) exhibited an isoform mobility shift on SDS-PAGE, consistent with the activation of the kinase. These data indicate that neither HRI nor GCN2 are required for the large increase in post-ischemic brain eIF2alpha(P), and in conjunction with our previous report that eIF2alpha(P) is produced in the brain of reperfused PKR-/- mice, provides evidence that PERK is the kinase responsible for eIF2alpha phosphorylation in the early post-ischemic brain. | lld:pubmed |
| pubmed-article:11389192 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389192 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389192 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389192 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389192 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11389192 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389192 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11389192 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389192 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11389192 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11389192 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11389192 | pubmed:issn | 0022-3042 | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:KumarRR | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:SullivanJ MJM | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:WhiteB CBC | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:ChenJ JJJ | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:HaoBB | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:RoyII | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:CavenerD RDR | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:OwenCC | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:ZhangPP | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:KrauseG SGS | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:DeGraciaD JDJ | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:HardingH PHP | lld:pubmed |
| pubmed-article:11389192 | pubmed:author | pubmed-author:AzamSS | lld:pubmed |
| pubmed-article:11389192 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11389192 | pubmed:volume | 77 | lld:pubmed |
| pubmed-article:11389192 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11389192 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11389192 | pubmed:pagination | 1418-21 | lld:pubmed |
| pubmed-article:11389192 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11389192 | pubmed:meshHeading | pubmed-meshheading:11389192... | lld:pubmed |
| pubmed-article:11389192 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11389192 | pubmed:articleTitle | Brain ischemia and reperfusion activates the eukaryotic initiation factor 2alpha kinase, PERK. | lld:pubmed |
| pubmed-article:11389192 | pubmed:affiliation | Department of Emergency Medicine, Wayne State University, Detroit, Michigan 48201, USA. | lld:pubmed |
| pubmed-article:11389192 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11389192 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11389192 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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