| pubmed-article:11387206 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11387206 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:11387206 | lifeskim:mentions | umls-concept:C0079414 | lld:lifeskim |
| pubmed-article:11387206 | lifeskim:mentions | umls-concept:C0258174 | lld:lifeskim |
| pubmed-article:11387206 | lifeskim:mentions | umls-concept:C1551336 | lld:lifeskim |
| pubmed-article:11387206 | lifeskim:mentions | umls-concept:C1565114 | lld:lifeskim |
| pubmed-article:11387206 | pubmed:issue | 11 | lld:pubmed |
| pubmed-article:11387206 | pubmed:dateCreated | 2001-6-1 | lld:pubmed |
| pubmed-article:11387206 | pubmed:abstractText | The membrane receptors DCC and UNC5H have been shown to be crucial for axon guidance and neuronal migration by acting as receptors for netrin-1. DCC has also been proposed as a dependence receptor inducing apoptosis in cells that are beyond netrin-1 availability. Here we show that the netrin-1 receptors UNC5H (UNC5H1, UNC5H2, UNC5H3) also act as dependence receptors. UNC5H receptors induce apoptosis, but this effect is blocked in the presence of netrin-1. Moreover, we demonstrate that UNC5H receptors are cleaved in vitro by caspase in their intracellular domains. This cleavage may lead to the exposure of a fragment encompassing a death domain required for cell death induction in vivo. Finally, we present evidence that during development of the nervous system, the presence of netrin-1 is crucial to maintain survival of UNC5H- and DCC-expressing neurons, especially in the ventricular zone of the brainstem. Altogether, these results argue for a role of netrin-1 during the development of the nervous system, not only as a guidance cue but as a survival factor via its receptors DCC and UNC5H. | lld:pubmed |
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| pubmed-article:11387206 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11387206 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11387206 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11387206 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11387206 | pubmed:issn | 0261-4189 | lld:pubmed |
| pubmed-article:11387206 | pubmed:author | pubmed-author:Bloch-Gallego... | lld:pubmed |
| pubmed-article:11387206 | pubmed:author | pubmed-author:MehleyEE | lld:pubmed |
| pubmed-article:11387206 | pubmed:author | pubmed-author:LlambiFF | lld:pubmed |
| pubmed-article:11387206 | pubmed:author | pubmed-author:CauseretFF | lld:pubmed |
| pubmed-article:11387206 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11387206 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11387206 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:11387206 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11387206 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11387206 | pubmed:pagination | 2715-22 | lld:pubmed |
| pubmed-article:11387206 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11387206 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11387206 | pubmed:articleTitle | Netrin-1 acts as a survival factor via its receptors UNC5H and DCC. | lld:pubmed |
| pubmed-article:11387206 | pubmed:affiliation | Apoptosis/Differentiation Laboratory-label La Ligue, Molecular and Cellular Genetic Center, CNRS UMR 5534, University of Lyon, 69622 Villeurbanne, France. | lld:pubmed |
| pubmed-article:11387206 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11387206 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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