| pubmed-article:11385577 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11385577 | lifeskim:mentions | umls-concept:C0012655 | lld:lifeskim |
| pubmed-article:11385577 | lifeskim:mentions | umls-concept:C0010346 | lld:lifeskim |
| pubmed-article:11385577 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:11385577 | lifeskim:mentions | umls-concept:C1826449 | lld:lifeskim |
| pubmed-article:11385577 | lifeskim:mentions | umls-concept:C0079380 | lld:lifeskim |
| pubmed-article:11385577 | pubmed:issue | 6837 | lld:pubmed |
| pubmed-article:11385577 | pubmed:dateCreated | 2001-5-31 | lld:pubmed |
| pubmed-article:11385577 | pubmed:abstractText | Crohn's disease is a chronic inflammatory disorder of the gastrointestinal tract, which is thought to result from the effect of environmental factors in a genetically predisposed host. A gene location in the pericentromeric region of chromosome 16, IBD1, that contributes to susceptibility to Crohn's disease has been established through multiple linkage studies, but the specific gene(s) has not been identified. NOD2, a gene that encodes a protein with homology to plant disease resistance gene products is located in the peak region of linkage on chromosome 16 (ref. 7). Here we show, by using the transmission disequilibium test and case-control analysis, that a frameshift mutation caused by a cytosine insertion, 3020insC, which is expected to encode a truncated NOD2 protein, is associated with Crohn's disease. Wild-type NOD2 activates nuclear factor NF-kappaB, making it responsive to bacterial lipopolysaccharides; however, this induction was deficient in mutant NOD2. These results implicate NOD2 in susceptibility to Crohn's disease, and suggest a link between an innate immune response to bacterial components and development of disease. | lld:pubmed |
| pubmed-article:11385577 | pubmed:commentsCorrections | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385577 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11385577 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385577 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11385577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385577 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11385577 | pubmed:month | May | lld:pubmed |
| pubmed-article:11385577 | pubmed:issn | 0028-0836 | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:DICKG HGH | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:BaylessT MTM | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:OguraYY | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:RamosRR | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:MoranTT | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:InoharaNN | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:KirschnerB... | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:BrittonHH | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:MouT WTW | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:BrantS RSR | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:HanauerS BSB | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:DuerrR HRH | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:BonenD KDK | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:NuñezGG | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:AchkarJ PJP | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:NicolaeD LDL | lld:pubmed |
| pubmed-article:11385577 | pubmed:author | pubmed-author:KaraliuskasRR | lld:pubmed |
| pubmed-article:11385577 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11385577 | pubmed:day | 31 | lld:pubmed |
| pubmed-article:11385577 | pubmed:volume | 411 | lld:pubmed |
| pubmed-article:11385577 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11385577 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11385577 | pubmed:pagination | 603-6 | lld:pubmed |
| pubmed-article:11385577 | pubmed:dateRevised | 2008-5-13 | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:meshHeading | pubmed-meshheading:11385577... | lld:pubmed |
| pubmed-article:11385577 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11385577 | pubmed:articleTitle | A frameshift mutation in NOD2 associated with susceptibility to Crohn's disease. | lld:pubmed |
| pubmed-article:11385577 | pubmed:affiliation | Department of Pathology and Comprehensive Cancer Center, The University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. | lld:pubmed |
| pubmed-article:11385577 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11385577 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11385577 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:64127 | entrezgene:pubmed | pubmed-article:11385577 | lld:entrezgene |
| http://linkedlifedata.com/r... | entrezgene:pubmed | pubmed-article:11385577 | lld:entrezgene |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11385577 | lld:pubmed |
