| pubmed-article:11385070 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11385070 | lifeskim:mentions | umls-concept:C0026848 | lld:lifeskim |
| pubmed-article:11385070 | lifeskim:mentions | umls-concept:C0085979 | lld:lifeskim |
| pubmed-article:11385070 | lifeskim:mentions | umls-concept:C0015127 | lld:lifeskim |
| pubmed-article:11385070 | lifeskim:mentions | umls-concept:C0036581 | lld:lifeskim |
| pubmed-article:11385070 | lifeskim:mentions | umls-concept:C0042875 | lld:lifeskim |
| pubmed-article:11385070 | lifeskim:mentions | umls-concept:C1314792 | lld:lifeskim |
| pubmed-article:11385070 | lifeskim:mentions | umls-concept:C1302234 | lld:lifeskim |
| pubmed-article:11385070 | lifeskim:mentions | umls-concept:C0205195 | lld:lifeskim |
| pubmed-article:11385070 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11385070 | pubmed:dateCreated | 2001-5-31 | lld:pubmed |
| pubmed-article:11385070 | pubmed:abstractText | Selenium and vitamin E deficiencies were studied as part of an evaluation of oxidant defenses in guinea pigs. Male guinea pigs (100-120 g) were fed a control diet (C) or the diet without selenium (0 Se), without vitamin E (0 E), or without either selenium or vitamin E (0 Se-0 E). Between d 30 and 35, 7 of 13 guinea pigs fed the 0 Se-0 E diet were euthanized because of severe weakness of their extremities. No guinea pigs in the other diet groups developed weakness. Guinea pigs from each group were killed on d 37. Selenium deficiency and vitamin E deficiency were verified by measurement of glutathione peroxidase and alpha-tocopherol. Creatine phophokinase (CPK) activity was greater than controls in both groups fed vitamin E-deficient diets, but the increase was greater in the 0 Se-0 E group than in the 0 E group. Muscle F(2)-isoprostanes were greater than controls in both groups fed vitamin E-deficient diets with the level in the 0 Se-0 E group greater than that in the 0 E group. Histologic muscle necrosis was severe in the 0 Se-0 E group, minimal in the 0 E group and absent from other groups. The diets used in this study induced selenium and vitamin E deficiencies in guinea pigs. The study demonstrates that combined selenium and vitamin E deficiency results in a fatal myopathy in guinea pigs that is associated with lipid peroxidation in the affected muscle. This nutritional myopathy is much more severe than the myopathy that occurs with vitamin E deficiency alone. | lld:pubmed |
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| pubmed-article:11385070 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385070 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11385070 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11385070 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11385070 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11385070 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11385070 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11385070 | pubmed:issn | 0022-3166 | lld:pubmed |
| pubmed-article:11385070 | pubmed:author | pubmed-author:BurkR FRF | lld:pubmed |
| pubmed-article:11385070 | pubmed:author | pubmed-author:HillK EKE | lld:pubmed |
| pubmed-article:11385070 | pubmed:author | pubmed-author:MayJ MJM | lld:pubmed |
| pubmed-article:11385070 | pubmed:author | pubmed-author:LULL | lld:pubmed |
| pubmed-article:11385070 | pubmed:author | pubmed-author:MotleyA KAK | lld:pubmed |
| pubmed-article:11385070 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11385070 | pubmed:volume | 131 | lld:pubmed |
| pubmed-article:11385070 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11385070 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11385070 | pubmed:pagination | 1798-802 | lld:pubmed |
| pubmed-article:11385070 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11385070 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11385070 | pubmed:articleTitle | Combined selenium and vitamin E deficiency causes fatal myopathy in guinea pigs. | lld:pubmed |
| pubmed-article:11385070 | pubmed:affiliation | Divisions of Gastroenterology and Endocrinology, Department of Medicine and Clinical Nutrition Research Unit, Vanderbilt University School of Medicine, Nashville, TN 37232-2279, USA. kristina.hill@mcmail.vanderbilt.edu | lld:pubmed |
| pubmed-article:11385070 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11385070 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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