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pubmed-article:11378366pubmed:abstractTextA series of aryloxy substituted piperazinones with dual farnesyltransferase/geranylgeranyltransferase-I inhibitory activity was prepared. These compounds were found to have potent inhibitory activity in vitro and are promising agents for the inhibition of Ki-Ras signaling.lld:pubmed
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pubmed-article:11378366pubmed:articleTitleAryloxy substituted N-arylpiperazinones as dual inhibitors of farnesyltransferase and geranylgeranyltransferase-I.lld:pubmed
pubmed-article:11378366pubmed:affiliationDepartment of Medicinal Chemistry, Merck Research Laboratories, West Point, PA 19486, USA.lld:pubmed
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