| pubmed-article:11376684 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11376684 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11376684 | lifeskim:mentions | umls-concept:C0268135 | lld:lifeskim |
| pubmed-article:11376684 | lifeskim:mentions | umls-concept:C1519346 | lld:lifeskim |
| pubmed-article:11376684 | lifeskim:mentions | umls-concept:C0028630 | lld:lifeskim |
| pubmed-article:11376684 | lifeskim:mentions | umls-concept:C0728940 | lld:lifeskim |
| pubmed-article:11376684 | pubmed:issue | 1-2 | lld:pubmed |
| pubmed-article:11376684 | pubmed:dateCreated | 2001-5-29 | lld:pubmed |
| pubmed-article:11376684 | pubmed:abstractText | Nucleotide excision repair (NER) removes a wide variety of lesions from the genome and is deficient in the genetic disorder, xeroderma pigmentosum (XP). In this paper, an in vitro analysis of the XP group A gene product (XPA protein) is reported. Results of an analysis on the pathogenesis of ultraviolet (UV)-B-induced skin cancer in the XPA gene-knockout mouse are also described: (1) contrary to wild type mice, significant bias of p53 mutations to the transcribed strand and no evident p53 mutational hot spots were detected in the skin tumors of XPA-knockout mice. (2) Skin cancer cell lines from UVB-irradiated XPA-knockout mice had a decreased mismatch repair activity and an abnormal cell cycle checkpoint, suggesting that the downregulation of mismatch repair helps cells escape killing by UVB and that mismatch repair-deficient clones are selected for during the tumorigenic transformation of XPA (-/-) cells. (3) The XPA-knockout mice showed a higher frequency of UVB-induced mutation in the rpsL transgene at a low dose of UVB-irradiation than the wild type mice. CC-->TT tandem transition, a hallmark of UV-induced mutation, was detected at higher frequency in the rpsL transgene in the XPA-knockout mice than the wild type mice. This rpsL/XPA mouse system will be useful for further analysing the role of NER in the mutagenesis induced by various carcinogens. (4) The UVB-induced immunosuppression was greatly enhanced in the XPA-knockout mice. It is possible that an enhanced impairment of the immune system by UVB irradiation is involved in the high incidence of skin cancer in XP. | lld:pubmed |
| pubmed-article:11376684 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11376684 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376684 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11376684 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376684 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376684 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376684 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376684 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11376684 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11376684 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11376684 | pubmed:issn | 0027-5107 | lld:pubmed |
| pubmed-article:11376684 | pubmed:author | pubmed-author:TanakaKK | lld:pubmed |
| pubmed-article:11376684 | pubmed:author | pubmed-author:HorioTT | lld:pubmed |
| pubmed-article:11376684 | pubmed:author | pubmed-author:SaikiTT | lld:pubmed |
| pubmed-article:11376684 | pubmed:author | pubmed-author:IchikawaMM | lld:pubmed |
| pubmed-article:11376684 | pubmed:author | pubmed-author:YoshinoMM | lld:pubmed |
| pubmed-article:11376684 | pubmed:author | pubmed-author:ReaLL | lld:pubmed |
| pubmed-article:11376684 | pubmed:author | pubmed-author:TakeuchiSS | lld:pubmed |
| pubmed-article:11376684 | pubmed:author | pubmed-author:MuraiHH | lld:pubmed |
| pubmed-article:11376684 | pubmed:author | pubmed-author:NakatsuYY | lld:pubmed |
| pubmed-article:11376684 | pubmed:author | pubmed-author:YonemasuRR | lld:pubmed |
| pubmed-article:11376684 | pubmed:author | pubmed-author:Miyauchi-Hash... | lld:pubmed |
| pubmed-article:11376684 | pubmed:author | pubmed-author:KamiuchiSS | lld:pubmed |
| pubmed-article:11376684 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11376684 | pubmed:day | 2 | lld:pubmed |
| pubmed-article:11376684 | pubmed:volume | 477 | lld:pubmed |
| pubmed-article:11376684 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11376684 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11376684 | pubmed:pagination | 31-40 | lld:pubmed |
| pubmed-article:11376684 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
| pubmed-article:11376684 | pubmed:meshHeading | pubmed-meshheading:11376684... | lld:pubmed |
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| pubmed-article:11376684 | pubmed:meshHeading | pubmed-meshheading:11376684... | lld:pubmed |
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| pubmed-article:11376684 | pubmed:meshHeading | pubmed-meshheading:11376684... | lld:pubmed |
| pubmed-article:11376684 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11376684 | pubmed:articleTitle | UV-induced skin carcinogenesis in xeroderma pigmentosum group A (XPA) gene-knockout mice with nucleotide excision repair-deficiency. | lld:pubmed |
| pubmed-article:11376684 | pubmed:affiliation | Institute for Molecular and Cellular Biology, Osaka University, 1-3 Yamadaoka, Suita, 565-0871, Osaka, Japan. ktanaka@imcb.osaka-u.ac.jp | lld:pubmed |
| pubmed-article:11376684 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:22590 | entrezgene:pubmed | pubmed-article:11376684 | lld:entrezgene |
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