| pubmed-article:11375812 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11375812 | lifeskim:mentions | umls-concept:C0020352 | lld:lifeskim |
| pubmed-article:11375812 | lifeskim:mentions | umls-concept:C0026385 | lld:lifeskim |
| pubmed-article:11375812 | lifeskim:mentions | umls-concept:C1280500 | lld:lifeskim |
| pubmed-article:11375812 | lifeskim:mentions | umls-concept:C1254881 | lld:lifeskim |
| pubmed-article:11375812 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11375812 | pubmed:dateCreated | 2001-5-28 | lld:pubmed |
| pubmed-article:11375812 | pubmed:abstractText | We evaluated the effect of various hydroxyethyl starch (HES) solutions on platelet function. Blood was obtained before and after the IV infusion (10 mL/kg) of saline (n = 10), HES 70/0.5--0.55 (molecular weight in kD/degree of substitution; n = 10), HES 130/0.38--0.45 (n = 10), HES 200/0.6--0.66 (n = 10), or HES 450/0.7--0.8 (n = 10) in otherwise healthy patients scheduled for elective surgery. Collagen and epinephrine were used as agonists for assessment of platelet function analyzer closure times. Flow cytometry was used to assess agonist-induced expression of activated glycoprotein IIb/IIIa complex and P-selectin. Infusion of HES 450/0.7--0.8, HES 200/0.6--0.66, and HES 70/0.5--0.55 prolonged closure times and reduced glycoprotein IIb/IIIa expression, whereas saline and HES 130/0.38--0.45 had no significant effect on platelet variables. P selectin expression was not affected by any solution tested. In vitro experiments demonstrated a less inhibiting effect of HES 130/0.38--0.45 on closure times when compared with other HES solutions. This study shows that HES 450/0.7--0.8, HES 200/0.6--0.66, and HES 70/0.5--0.55 inhibit platelet function by reducing the availability of the functional receptor for fibrinogen on the platelet surface. Our data indicate that fluid resuscitation with HES 130/0.38--0.45 may reduce the risk of bleeding associated with synthetic colloids of higher molecular weight and degree of substitution. | lld:pubmed |
| pubmed-article:11375812 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11375812 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11375812 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11375812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11375812 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11375812 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11375812 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11375812 | pubmed:issn | 0003-2999 | lld:pubmed |
| pubmed-article:11375812 | pubmed:author | pubmed-author:FranzAA | lld:pubmed |
| pubmed-article:11375812 | pubmed:author | pubmed-author:FelfernigMM | lld:pubmed |
| pubmed-article:11375812 | pubmed:author | pubmed-author:Kozek-Langene... | lld:pubmed |
| pubmed-article:11375812 | pubmed:author | pubmed-author:GustorffBB | lld:pubmed |
| pubmed-article:11375812 | pubmed:author | pubmed-author:BräunlichPP | lld:pubmed |
| pubmed-article:11375812 | pubmed:author | pubmed-author:GamsjägerTT | lld:pubmed |
| pubmed-article:11375812 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11375812 | pubmed:volume | 92 | lld:pubmed |
| pubmed-article:11375812 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11375812 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11375812 | pubmed:pagination | 1402-7 | lld:pubmed |
| pubmed-article:11375812 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
| pubmed-article:11375812 | pubmed:meshHeading | pubmed-meshheading:11375812... | lld:pubmed |
| pubmed-article:11375812 | pubmed:meshHeading | pubmed-meshheading:11375812... | lld:pubmed |
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| pubmed-article:11375812 | pubmed:meshHeading | pubmed-meshheading:11375812... | lld:pubmed |
| pubmed-article:11375812 | pubmed:meshHeading | pubmed-meshheading:11375812... | lld:pubmed |
| pubmed-article:11375812 | pubmed:meshHeading | pubmed-meshheading:11375812... | lld:pubmed |
| pubmed-article:11375812 | pubmed:meshHeading | pubmed-meshheading:11375812... | lld:pubmed |
| pubmed-article:11375812 | pubmed:meshHeading | pubmed-meshheading:11375812... | lld:pubmed |
| pubmed-article:11375812 | pubmed:meshHeading | pubmed-meshheading:11375812... | lld:pubmed |
| pubmed-article:11375812 | pubmed:meshHeading | pubmed-meshheading:11375812... | lld:pubmed |
| pubmed-article:11375812 | pubmed:meshHeading | pubmed-meshheading:11375812... | lld:pubmed |
| pubmed-article:11375812 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11375812 | pubmed:articleTitle | The effects of hydroxyethyl starches of varying molecular weights on platelet function. | lld:pubmed |
| pubmed-article:11375812 | pubmed:affiliation | Department of Anesthesiology and Intensive Care B, University of Vienna, School of Medicine, Vienna, Austria. | lld:pubmed |
| pubmed-article:11375812 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11375812 | pubmed:publicationType | Clinical Trial | lld:pubmed |
| pubmed-article:11375812 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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