Linked Life Data

11374610

Source:http://linkedlifedata.com/resource/pubmed/id/11374610

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pubmed-article:11374610pubmed:abstractTextThe alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) subtype of glutamate receptor mediates fast excitatory neurotransmission in the central nervous system. Many general anesthetics inhibit AMPA receptors in vitro; however, it is not certain if this inhibition contributes to the behavioral properties of these drugs. AMPA receptors lacking the GluR2 subunit are resistant to blockade by barbiturates in vitro. Paradoxically, GluR2 null mutant (-/-) mice are more sensitive to barbiturate-induced loss of the righting reflex (LORR) compared with wild-type (+/+) littermates. To determine if interactions between anesthetics and AMPA receptors account for the increased sensitivity of (-/-) mice, the effects of volatile anesthetics that do not directly inhibit AMPA receptors were examined.lld:pubmed
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pubmed-article:11374610pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:11374610pubmed:articleTitleBlockade of AMPA receptors and volatile anesthetics: reduced anesthetic requirements in GluR2 null mutant mice for loss of the righting reflex and antinociception but not minimum alveolar concentration.lld:pubmed
pubmed-article:11374610pubmed:affiliationDepartment of Anesthesia, University of Toronto, Ontario, Canada.lld:pubmed
pubmed-article:11374610pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11374610pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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