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pubmed-article:11374595pubmed:abstractTextRecent studies have determined that an initial rectal acetaminophen dose of approximately 40 mg/kg is needed in children to achieve target antipyretic serum concentrations. The timing and amount of subsequent doses after a 40-mg/kg dose has not been clarified for this route of administration. Based on the authors' previous pharmacokinetic data, they examined whether a 40-mg/kg loading dose followed by 20-mg/kg doses at 6-h intervals maintain serum concentrations within the target range of 10-20 microg/ml, without evidence of accumulation.lld:pubmed
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pubmed-article:11374595pubmed:articleTitleInitial and subsequent dosing of rectal acetaminophen in children: a 24-hour pharmacokinetic study of new dose recommendations.lld:pubmed
pubmed-article:11374595pubmed:affiliationNorthwestern University at Children's Memorial Hospital, Chicago, Illinois 60614-3394, USA. pbirming@nwu.edulld:pubmed
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