| pubmed-article:11371349 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11371349 | lifeskim:mentions | umls-concept:C1123023 | lld:lifeskim |
| pubmed-article:11371349 | lifeskim:mentions | umls-concept:C0105770 | lld:lifeskim |
| pubmed-article:11371349 | lifeskim:mentions | umls-concept:C1523544 | lld:lifeskim |
| pubmed-article:11371349 | lifeskim:mentions | umls-concept:C1820288 | lld:lifeskim |
| pubmed-article:11371349 | lifeskim:mentions | umls-concept:C2587213 | lld:lifeskim |
| pubmed-article:11371349 | pubmed:issue | 4 | lld:pubmed |
| pubmed-article:11371349 | pubmed:dateCreated | 2001-5-23 | lld:pubmed |
| pubmed-article:11371349 | pubmed:abstractText | beta-Catenin is an essential molecule in Wnt/wingless signaling, which controls decisive steps in embryogenesis. To study the role of beta-catenin in skin development, we introduced a conditional mutation of the gene in the epidermis and hair follicles using Cre/loxP technology. When beta-catenin is mutated during embryogenesis, formation of placodes that generate hair follicles is blocked. We show that beta-catenin is required genetically downstream of tabby/downless and upstream of bmp and shh in placode formation. If beta-catenin is deleted after hair follicles have formed, hair is completely lost after the first hair cycle. Further analysis demonstrates that beta-catenin is essential for fate decisions of skin stem cells: in the absence of beta-catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate. | lld:pubmed |
| pubmed-article:11371349 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11371349 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11371349 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11371349 | pubmed:month | May | lld:pubmed |
| pubmed-article:11371349 | pubmed:issn | 0092-8674 | lld:pubmed |
| pubmed-article:11371349 | pubmed:author | pubmed-author:VogelRR | lld:pubmed |
| pubmed-article:11371349 | pubmed:author | pubmed-author:BirchmeierWW | lld:pubmed |
| pubmed-article:11371349 | pubmed:author | pubmed-author:ErdmannBB | lld:pubmed |
| pubmed-article:11371349 | pubmed:author | pubmed-author:CotsarelisGG | lld:pubmed |
| pubmed-article:11371349 | pubmed:author | pubmed-author:HuelskenJJ | lld:pubmed |
| pubmed-article:11371349 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11371349 | pubmed:day | 18 | lld:pubmed |
| pubmed-article:11371349 | pubmed:volume | 105 | lld:pubmed |
| pubmed-article:11371349 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11371349 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11371349 | pubmed:pagination | 533-45 | lld:pubmed |
| pubmed-article:11371349 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11371349 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11371349 | pubmed:articleTitle | beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin. | lld:pubmed |
| pubmed-article:11371349 | pubmed:affiliation | Max-Delbrueck-Center for Molecular Medicine, Robert-Roessle-Strasse 10, 13092, Berlin, Germany. | lld:pubmed |
| pubmed-article:11371349 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11371349 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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