| pubmed-article:11369788 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11369788 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
| pubmed-article:11369788 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11369788 | lifeskim:mentions | umls-concept:C0218158 | lld:lifeskim |
| pubmed-article:11369788 | lifeskim:mentions | umls-concept:C0312738 | lld:lifeskim |
| pubmed-article:11369788 | lifeskim:mentions | umls-concept:C1708726 | lld:lifeskim |
| pubmed-article:11369788 | lifeskim:mentions | umls-concept:C0021037 | lld:lifeskim |
| pubmed-article:11369788 | lifeskim:mentions | umls-concept:C0017287 | lld:lifeskim |
| pubmed-article:11369788 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11369788 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11369788 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11369788 | pubmed:dateCreated | 2001-5-22 | lld:pubmed |
| pubmed-article:11369788 | pubmed:abstractText | Bruton's tyrosine kinase (Btk) is a nonreceptor tyrosine kinase involved in precursor B (pre-B) cell receptor signaling. Here we demonstrate that Btk-deficient mice have an approximately 50% reduction in the frequency of immunoglobulin (Ig) lambda light chain expression, already at the immature B cell stage in the bone marrow. Conversely, transgenic mice expressing the activated mutant Btk(E41K) showed increased lambda usage. As the kappa/lambda ratio is dependent on (a) the level and kinetics of kappa and lambda locus activation, (b) the life span of pre-B cells, and (c) the extent of receptor editing, we analyzed the role of Btk in these processes. Enforced expression of the Bcl-2 apoptosis inhibitor did not alter the Btk dependence of lambda usage. Crossing 3-83mudelta autoantibody transgenic mice into Btk-deficient mice showed that Btk is not essential for receptor editing. Also, Btk-deficient surface Ig(+) B cells that were generated in vitro in interleukin 7-driven bone marrow cultures manifested reduced lambda usage. An intrinsic defect in lambda locus recombination was further supported by the finding in Btk-deficient mice of reduced lambda usage in the fraction of pre-B cells that express light chains in their cytoplasm. These results implicate Btk in the regulation of the activation of the lambda locus for V(D)J recombination in pre-B cells. | lld:pubmed |
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| pubmed-article:11369788 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11369788 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11369788 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11369788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11369788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11369788 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11369788 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11369788 | pubmed:month | May | lld:pubmed |
| pubmed-article:11369788 | pubmed:issn | 0022-1007 | lld:pubmed |
| pubmed-article:11369788 | pubmed:author | pubmed-author:MaasAA | lld:pubmed |
| pubmed-article:11369788 | pubmed:author | pubmed-author:HendriksR WRW | lld:pubmed |
| pubmed-article:11369788 | pubmed:author | pubmed-author:GrosveldFF | lld:pubmed |
| pubmed-article:11369788 | pubmed:author | pubmed-author:DingjanG MGM | lld:pubmed |
| pubmed-article:11369788 | pubmed:author | pubmed-author:MiddendorpSS | lld:pubmed |
| pubmed-article:11369788 | pubmed:author | pubmed-author:DahlenborgKK | lld:pubmed |
| pubmed-article:11369788 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11369788 | pubmed:day | 21 | lld:pubmed |
| pubmed-article:11369788 | pubmed:volume | 193 | lld:pubmed |
| pubmed-article:11369788 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11369788 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11369788 | pubmed:pagination | 1169-78 | lld:pubmed |
| pubmed-article:11369788 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:meshHeading | pubmed-meshheading:11369788... | lld:pubmed |
| pubmed-article:11369788 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11369788 | pubmed:articleTitle | Bruton's tyrosine kinase regulates the activation of gene rearrangements at the lambda light chain locus in precursor B cells in the mouse. | lld:pubmed |
| pubmed-article:11369788 | pubmed:affiliation | Department of Immunology, Faculty of Medicine, Erasmus University Rotterdam, 3000 DR Rotterdam, The Netherlands. | lld:pubmed |
| pubmed-article:11369788 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11369788 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
