Linked Life Data

11369202

Source:http://linkedlifedata.com/resource/pubmed/id/11369202

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pubmed-article:11369202pubmed:abstractTextMammalian megakaryocytes release blood platelets through a remarkable process of cytoplasmic fragmentation and de novo assembly of a marginal microtubule band. Cell-specific components of this process include the divergent beta-tubulin isoform beta1 that is expressed exclusively, and is the predominant isoform, in platelets and megakaryocytes. The functional significance of this restricted expression, and indeed of the surprisingly large repertoire of metazoan tubulin genes, is unclear. Fungal tubulin isoforms appear to be functionally redundant, and all mammalian beta-tubulins can assemble in a variety of microtubules, whereas selected fly and worm beta-tubulins are essential in spermatogenesis and neurogenesis. To address the essential role of beta1-tubulin in its natural context, we generated mice with targeted gene disruption.lld:pubmed
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pubmed-article:11369202pubmed:articleTitleA lineage-restricted and divergent beta-tubulin isoform is essential for the biogenesis, structure and function of blood platelets.lld:pubmed
pubmed-article:11369202pubmed:affiliationDepartment of Adult Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA.lld:pubmed
pubmed-article:11369202pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11369202pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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