| pubmed-article:11358800 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11358800 | lifeskim:mentions | umls-concept:C0376358 | lld:lifeskim |
| pubmed-article:11358800 | lifeskim:mentions | umls-concept:C0379710 | lld:lifeskim |
| pubmed-article:11358800 | lifeskim:mentions | umls-concept:C1704387 | lld:lifeskim |
| pubmed-article:11358800 | lifeskim:mentions | umls-concept:C0007620 | lld:lifeskim |
| pubmed-article:11358800 | lifeskim:mentions | umls-concept:C1522642 | lld:lifeskim |
| pubmed-article:11358800 | lifeskim:mentions | umls-concept:C0027627 | lld:lifeskim |
| pubmed-article:11358800 | lifeskim:mentions | umls-concept:C1327616 | lld:lifeskim |
| pubmed-article:11358800 | lifeskim:mentions | umls-concept:C0018270 | lld:lifeskim |
| pubmed-article:11358800 | lifeskim:mentions | umls-concept:C1880177 | lld:lifeskim |
| pubmed-article:11358800 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11358800 | pubmed:dateCreated | 2001-5-18 | lld:pubmed |
| pubmed-article:11358800 | pubmed:abstractText | Caveolin-1 is an integral protein of caveolae, known to play important roles in signal transduction and lipid transport. We demonstrate that caveolin-1 expression is significantly increased in primary and metastatic human prostate cancer after androgen ablation therapy. We also show that caveolin-1 is secreted by androgen-insensitive prostate cancer cells, and that this secretion is regulated by steroid hormones. Significantly, caveolin-1 was detected in the MDL(3) fraction of serum specimens from patients with advanced prostate cancer and to a lesser extent in normal subjects. Conditioned media from high passage caveolin-1 secreting, androgen-insensitive, LNCaP cells stimulated increased viability and clonal growth of low passage, caveolin-1-negative, androgen-sensitive, LNCaP cells in vitro, and this effect was blocked by treating the media with caveolin-1 antibody. i.p. injections of caveolin-1 antibody suppressed the orthotopic growth and spontaneous metastasis of highly metastatic, androgen-insensitive caveolin-1-secreting mouse prostate cancer. Overall, our results establish caveolin-1 as an autocrine/paracrine factor that is associated with androgen-insensitive prostate cancer. We demonstrate the potential for caveolin-1 as a therapeutic target for this important malignancy. | lld:pubmed |
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| pubmed-article:11358800 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11358800 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11358800 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11358800 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11358800 | pubmed:month | May | lld:pubmed |
| pubmed-article:11358800 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:11358800 | pubmed:author | pubmed-author:SatohTT | lld:pubmed |
| pubmed-article:11358800 | pubmed:author | pubmed-author:LORR | lld:pubmed |
| pubmed-article:11358800 | pubmed:author | pubmed-author:MorrisettJ... | lld:pubmed |
| pubmed-article:11358800 | pubmed:author | pubmed-author:YanoOO | lld:pubmed |
| pubmed-article:11358800 | pubmed:author | pubmed-author:EbaraSS | lld:pubmed |
| pubmed-article:11358800 | pubmed:author | pubmed-author:ThompsonT CTC | lld:pubmed |
| pubmed-article:11358800 | pubmed:author | pubmed-author:TimmeT LTL | lld:pubmed |
| pubmed-article:11358800 | pubmed:author | pubmed-author:IttmannMM | lld:pubmed |
| pubmed-article:11358800 | pubmed:author | pubmed-author:GoltsovAA | lld:pubmed |
| pubmed-article:11358800 | pubmed:author | pubmed-author:TahirS ASA | lld:pubmed |
| pubmed-article:11358800 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11358800 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11358800 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:11358800 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11358800 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11358800 | pubmed:pagination | 3882-5 | lld:pubmed |
| pubmed-article:11358800 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
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| pubmed-article:11358800 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11358800 | pubmed:articleTitle | Secreted caveolin-1 stimulates cell survival/clonal growth and contributes to metastasis in androgen-insensitive prostate cancer. | lld:pubmed |
| pubmed-article:11358800 | pubmed:affiliation | Scott Department of Urology, Baylor College of Medicine, 6560 Fannin Street, Houston, Texas 77030, USA. | lld:pubmed |
| pubmed-article:11358800 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11358800 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11358800 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
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