| pubmed-article:11350769 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11350769 | lifeskim:mentions | umls-concept:C0020971 | lld:lifeskim |
| pubmed-article:11350769 | lifeskim:mentions | umls-concept:C0034693 | lld:lifeskim |
| pubmed-article:11350769 | lifeskim:mentions | umls-concept:C0597295 | lld:lifeskim |
| pubmed-article:11350769 | lifeskim:mentions | umls-concept:C0015259 | lld:lifeskim |
| pubmed-article:11350769 | lifeskim:mentions | umls-concept:C0021665 | lld:lifeskim |
| pubmed-article:11350769 | lifeskim:mentions | umls-concept:C0442805 | lld:lifeskim |
| pubmed-article:11350769 | lifeskim:mentions | umls-concept:C0683598 | lld:lifeskim |
| pubmed-article:11350769 | lifeskim:mentions | umls-concept:C1292733 | lld:lifeskim |
| pubmed-article:11350769 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11350769 | pubmed:dateCreated | 2001-5-14 | lld:pubmed |
| pubmed-article:11350769 | pubmed:abstractText | These studies examined whether passive immunization against insulin-like growth factor I (IGF-I) would prevent increases in rates of protein synthesis in skeletal muscle of diabetic rats after resistance exercise. Male Sprague-Dawley rats were pancreatectomized and randomly assigned to either an exercise or a sedentary group. Animals in each of these groups received either an IGF-I antibody or a nonspecific IgG from a subcutaneous osmotic pump. Exercise did not change plasma or gastrocnemius IGF-I concentrations in nondiabetic rats. However, plasma and muscle IGF-I concentrations were higher in IgG-treated diabetic rats that exercised compared with respective sedentary groups (P < 0.05). Passively immunized diabetic rats did not exhibit the same exercise-induced increase in IGF-I concentrations. In nondiabetic rats, protein synthesis rates were higher after exercise in both control and immunized groups. In diabetic rats, exercise increased protein synthesis in the IgG-treated animals but not in those treated with IGF-I antibody. There was also a significant positive correlation between both plasma and gastrocnemius IGF-I concentrations and rates of protein synthesis in diabetic (P < 0.01), but not nondiabetic, rats. These results suggest that IGF-I is compensatory for insulin in hypoinsulinemic rats by facilitating an anabolic response after acute resistance exercise. | lld:pubmed |
| pubmed-article:11350769 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11350769 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11350769 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11350769 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11350769 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11350769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11350769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11350769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11350769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11350769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11350769 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11350769 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11350769 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11350769 | pubmed:issn | 0193-1849 | lld:pubmed |
| pubmed-article:11350769 | pubmed:author | pubmed-author:FarrellP APA | lld:pubmed |
| pubmed-article:11350769 | pubmed:author | pubmed-author:LangC HCH | lld:pubmed |
| pubmed-article:11350769 | pubmed:author | pubmed-author:FedeleM JMJ | lld:pubmed |
| pubmed-article:11350769 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11350769 | pubmed:volume | 280 | lld:pubmed |
| pubmed-article:11350769 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11350769 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11350769 | pubmed:pagination | E877-85 | lld:pubmed |
| pubmed-article:11350769 | pubmed:dateRevised | 2011-11-17 | lld:pubmed |
| pubmed-article:11350769 | pubmed:meshHeading | pubmed-meshheading:11350769... | lld:pubmed |
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| pubmed-article:11350769 | pubmed:meshHeading | pubmed-meshheading:11350769... | lld:pubmed |
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| pubmed-article:11350769 | pubmed:meshHeading | pubmed-meshheading:11350769... | lld:pubmed |
| pubmed-article:11350769 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11350769 | pubmed:articleTitle | Immunization against IGF-I prevents increases in protein synthesis in diabetic rats after resistance exercise. | lld:pubmed |
| pubmed-article:11350769 | pubmed:affiliation | Noll Physiological Research Center, Pennsylvania State University, University Park, PA 16802, USA. mfedele@uic.edu | lld:pubmed |
| pubmed-article:11350769 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11350769 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
