| pubmed-article:11343700 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11343700 | lifeskim:mentions | umls-concept:C0033634 | lld:lifeskim |
| pubmed-article:11343700 | lifeskim:mentions | umls-concept:C0598312 | lld:lifeskim |
| pubmed-article:11343700 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:11343700 | lifeskim:mentions | umls-concept:C1879547 | lld:lifeskim |
| pubmed-article:11343700 | lifeskim:mentions | umls-concept:C0441712 | lld:lifeskim |
| pubmed-article:11343700 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11343700 | pubmed:dateCreated | 2001-5-9 | lld:pubmed |
| pubmed-article:11343700 | pubmed:abstractText | We present evidence that gastrin, binding to a G protein-coupled receptor, activates the p38-mitogen-activated protein kinase (MAPK) pathway. Blockage of protein kinase C (PKC) by GF109203X, depletion of intracellular calcium by thapsigargin or inhibition of Src family kinases by PP2 prevented p38-MAPK activation and the Src kinase activity stimulated by gastrin. Inhibition of the PI 3-kinase by wortmannin or LY294002 did not affect these responses. In addition, the p38-MAPK inhibitor, SB203580, repressed gastrin-induced [(3)H]thymidine incorporation, indicating a major role of p38-MAPK in the growth-promoting effect of gastrin. Our results demonstrate that gastrin-induced DNA synthesis requires p38-MAPK activation through mechanisms that involve calcium mobilization, PKC and Src family kinases. | lld:pubmed |
| pubmed-article:11343700 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11343700 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11343700 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11343700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11343700 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11343700 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11343700 | pubmed:month | May | lld:pubmed |
| pubmed-article:11343700 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:11343700 | pubmed:author | pubmed-author:PradayrolLL | lld:pubmed |
| pubmed-article:11343700 | pubmed:author | pubmed-author:SevaCC | lld:pubmed |
| pubmed-article:11343700 | pubmed:author | pubmed-author:Kowalski-Chau... | lld:pubmed |
| pubmed-article:11343700 | pubmed:author | pubmed-author:FourmyDD | lld:pubmed |
| pubmed-article:11343700 | pubmed:author | pubmed-author:DaulhacLL | lld:pubmed |
| pubmed-article:11343700 | pubmed:author | pubmed-author:DehezSS | lld:pubmed |
| pubmed-article:11343700 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11343700 | pubmed:day | 4 | lld:pubmed |
| pubmed-article:11343700 | pubmed:volume | 496 | lld:pubmed |
| pubmed-article:11343700 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11343700 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11343700 | pubmed:pagination | 25-30 | lld:pubmed |
| pubmed-article:11343700 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11343700 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11343700 | pubmed:articleTitle | Gastrin-induced DNA synthesis requires p38-MAPK activation via PKC/Ca(2+) and Src-dependent mechanisms. | lld:pubmed |
| pubmed-article:11343700 | pubmed:affiliation | Groupe de Recherche de Biologie et Pathologie Digestives, INSERM U.531, CHU Rangueil, 1 avenue J. Poulhes, Institut Louis Bugnard, Bat. L3, 31403 Toulouse, France. | lld:pubmed |
| pubmed-article:11343700 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11343700 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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