| pubmed-article:11342638 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11342638 | lifeskim:mentions | umls-concept:C0058980 | lld:lifeskim |
| pubmed-article:11342638 | lifeskim:mentions | umls-concept:C1704259 | lld:lifeskim |
| pubmed-article:11342638 | lifeskim:mentions | umls-concept:C1749855 | lld:lifeskim |
| pubmed-article:11342638 | lifeskim:mentions | umls-concept:C1705987 | lld:lifeskim |
| pubmed-article:11342638 | lifeskim:mentions | umls-concept:C1546857 | lld:lifeskim |
| pubmed-article:11342638 | lifeskim:mentions | umls-concept:C1556066 | lld:lifeskim |
| pubmed-article:11342638 | lifeskim:mentions | umls-concept:C1619636 | lld:lifeskim |
| pubmed-article:11342638 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11342638 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11342638 | pubmed:dateCreated | 2001-5-8 | lld:pubmed |
| pubmed-article:11342638 | pubmed:abstractText | The IFN-inducible dsRNA-activated protein kinase PKR regulates protein synthesis through phosphorylation of eukaryotic initiation factor-2alpha. It also acts as a signal transducer for transcription factors NF-kappaB, IFN regulatory factor-1, and activating transcription factor-2. IFN-gamma, a pleiotropic cytokine, elicits gene expression by activating the Janus kinase-STAT signaling pathway. IFN-gamma can synergize with TNF-alpha to activate NF-kappaB in a number of cell lines. Here we show that IFN-gamma alone can activate NF-kappaB, by a Janus kinase-1-mediated, but Stat1-independent, mechanism. NF-kappaB activation by IFN-gamma is associated with degradation of IkappaB beta. The IFN-gamma response can be blocked by 2',5'-oligoadenylate-linked antisense chimeras against PKR mRNA. There was no activation of NF-kappaB by IFN in PKR-null cells, indicating that PKR is required for IFN-gamma signaling to NF-kappaB. | lld:pubmed |
| pubmed-article:11342638 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11342638 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11342638 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11342638 | pubmed:citationSubset | AIM | lld:pubmed |
| pubmed-article:11342638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11342638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11342638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11342638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11342638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11342638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11342638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11342638 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11342638 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11342638 | pubmed:month | May | lld:pubmed |
| pubmed-article:11342638 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11342638 | pubmed:author | pubmed-author:WilliamsB RBR | lld:pubmed |
| pubmed-article:11342638 | pubmed:author | pubmed-author:MogensenTT | lld:pubmed |
| pubmed-article:11342638 | pubmed:author | pubmed-author:DexWW | lld:pubmed |
| pubmed-article:11342638 | pubmed:author | pubmed-author:SilvermanR... | lld:pubmed |
| pubmed-article:11342638 | pubmed:author | pubmed-author:HaqueS JSJ | lld:pubmed |
| pubmed-article:11342638 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11342638 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11342638 | pubmed:volume | 166 | lld:pubmed |
| pubmed-article:11342638 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11342638 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11342638 | pubmed:pagination | 6170-80 | lld:pubmed |
| pubmed-article:11342638 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11342638 | pubmed:meshHeading | pubmed-meshheading:11342638... | lld:pubmed |
| pubmed-article:11342638 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11342638 | pubmed:articleTitle | RNA-dependent protein kinase PKR is required for activation of NF-kappa B by IFN-gamma in a STAT1-independent pathway. | lld:pubmed |
| pubmed-article:11342638 | pubmed:affiliation | Department of Cancer Biology, The Lerner Research Institute, Cleveland Clinic Foundation, Cleveland, OH 44195, USA. | lld:pubmed |
| pubmed-article:11342638 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11342638 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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