| pubmed-article:11342578 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11342578 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11342578 | lifeskim:mentions | umls-concept:C0383327 | lld:lifeskim |
| pubmed-article:11342578 | lifeskim:mentions | umls-concept:C0022660 | lld:lifeskim |
| pubmed-article:11342578 | lifeskim:mentions | umls-concept:C0221099 | lld:lifeskim |
| pubmed-article:11342578 | lifeskim:mentions | umls-concept:C0475224 | lld:lifeskim |
| pubmed-article:11342578 | lifeskim:mentions | umls-concept:C1709694 | lld:lifeskim |
| pubmed-article:11342578 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11342578 | pubmed:dateCreated | 2001-5-8 | lld:pubmed |
| pubmed-article:11342578 | pubmed:abstractText | We sought to determine whether mice deficient in the proinflammatory caspase-1, which cleaves precursors of IL-1 beta and IL-18, were protected against ischemic acute renal failure (ARF). Caspase-1(-/-) mice developed less ischemic ARF as judged by renal function and renal histology. These animals had significantly reduced blood urea nitrogen and serum creatinine levels and a lower morphological tubular necrosis score than did wild-type mice with ischemic ARF. Since caspase-1 activates IL-18, lack of mature IL-18 might protect these caspase-1(-/-) mice from ARF. In wild-type animals, we found that ARF causes kidney IL-18 levels to more than double and induces the conversion of the IL-18 precursor to the mature form. This conversion is not observed in caspase-1(-/-) ARF mice or sham-operated controls. We then injected wild-type mice with IL-18-neutralizing antiserum before the ischemic insult and found a similar degree of protection from ARF as seen in caspase-1(-/-) mice. In addition, we observed a fivefold increase in myeloperoxidase activity in control mice with ARF, but no such increase in caspase-1(-/-) or IL-18 antiserum-treated mice. Finally, we confirmed histologically that caspase-1(-/-) mice show decreased neutrophil infiltration, indicating that the deleterious role of IL-18 in ischemic ARF may be due to increased neutrophil infiltration. | lld:pubmed |
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| pubmed-article:11342578 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11342578 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11342578 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11342578 | pubmed:month | May | lld:pubmed |
| pubmed-article:11342578 | pubmed:issn | 0021-9738 | lld:pubmed |
| pubmed-article:11342578 | pubmed:author | pubmed-author:SchrierR WRW | lld:pubmed |
| pubmed-article:11342578 | pubmed:author | pubmed-author:DinarelloC... | lld:pubmed |
| pubmed-article:11342578 | pubmed:author | pubmed-author:LuciaM SMS | lld:pubmed |
| pubmed-article:11342578 | pubmed:author | pubmed-author:SiegmundBB | lld:pubmed |
| pubmed-article:11342578 | pubmed:author | pubmed-author:EdelsteinC... | lld:pubmed |
| pubmed-article:11342578 | pubmed:author | pubmed-author:FantuzziGG | lld:pubmed |
| pubmed-article:11342578 | pubmed:author | pubmed-author:EcderTT | lld:pubmed |
| pubmed-article:11342578 | pubmed:author | pubmed-author:MelnikovV YVY | lld:pubmed |
| pubmed-article:11342578 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11342578 | pubmed:volume | 107 | lld:pubmed |
| pubmed-article:11342578 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11342578 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11342578 | pubmed:pagination | 1145-52 | lld:pubmed |
| pubmed-article:11342578 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11342578 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11342578 | pubmed:articleTitle | Impaired IL-18 processing protects caspase-1-deficient mice from ischemic acute renal failure. | lld:pubmed |
| pubmed-article:11342578 | pubmed:affiliation | Department of Medicine, University of Colorado School of Medicine, Denver, Colorado 80262, USA. | lld:pubmed |
| pubmed-article:11342578 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11342578 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11342578 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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