| pubmed-article:11334882 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11334882 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11334882 | lifeskim:mentions | umls-concept:C0043393 | lld:lifeskim |
| pubmed-article:11334882 | lifeskim:mentions | umls-concept:C0682323 | lld:lifeskim |
| pubmed-article:11334882 | lifeskim:mentions | umls-concept:C1704675 | lld:lifeskim |
| pubmed-article:11334882 | lifeskim:mentions | umls-concept:C1421437 | lld:lifeskim |
| pubmed-article:11334882 | lifeskim:mentions | umls-concept:C1333653 | lld:lifeskim |
| pubmed-article:11334882 | lifeskim:mentions | umls-concept:C1414357 | lld:lifeskim |
| pubmed-article:11334882 | lifeskim:mentions | umls-concept:C1167622 | lld:lifeskim |
| pubmed-article:11334882 | lifeskim:mentions | umls-concept:C2603343 | lld:lifeskim |
| pubmed-article:11334882 | pubmed:issue | 3 | lld:pubmed |
| pubmed-article:11334882 | pubmed:dateCreated | 2001-5-3 | lld:pubmed |
| pubmed-article:11334882 | pubmed:abstractText | p97/Gab2 is a recently characterized member of a large family of scaffold proteins that play essential roles in signal transduction. Gab2 becomes tyrosine-phosphorylated in response to a variety of growth factors and forms multimolecular complexes with SH2 domain-containing signaling molecules such as the p85-regulatory subunit of the phosphoinositide-3-kinase (p85-PI3K), the tyrosine phosphatase SHP-2 and the adapter protein CrkL. To characterize the interactions between Gab2 and its SH2-containing binding partners, we designed a modified yeast two-hybrid system in which the Lyn tyrosine kinase is expressed in a regulated manner in yeast. Using this assay, we demonstrated that p97/Gab2 specifically interacts with the SH2 domains of PI3K, SHP-2 and CrkL. Interaction with p85-PI3K is mediated by tyrosine residues Y452, Y476 and Y584 of Gab2, while interaction with SHP-2 depends exclusively on tyrosine Y614. CrkL interaction is mediated by its SH2 domain recognizing Y266 and Y293, despite the latter being in a non-consensus (YTFK) environment. | lld:pubmed |
| pubmed-article:11334882 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11334882 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11334882 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11334882 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11334882 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11334882 | pubmed:issn | 0014-5793 | lld:pubmed |
| pubmed-article:11334882 | pubmed:author | pubmed-author:ArnaudMM | lld:pubmed |
| pubmed-article:11334882 | pubmed:author | pubmed-author:BertoglioJJ | lld:pubmed |
| pubmed-article:11334882 | pubmed:author | pubmed-author:GesbertFF | lld:pubmed |
| pubmed-article:11334882 | pubmed:author | pubmed-author:CamonisJJ | lld:pubmed |
| pubmed-article:11334882 | pubmed:author | pubmed-author:CrouinCC | lld:pubmed |
| pubmed-article:11334882 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11334882 | pubmed:day | 27 | lld:pubmed |
| pubmed-article:11334882 | pubmed:volume | 495 | lld:pubmed |
| pubmed-article:11334882 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11334882 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11334882 | pubmed:pagination | 148-53 | lld:pubmed |
| pubmed-article:11334882 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11334882 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11334882 | pubmed:articleTitle | A yeast two-hybrid study of human p97/Gab2 interactions with its SH2 domain-containing binding partners. | lld:pubmed |
| pubmed-article:11334882 | pubmed:affiliation | Inserm Unit 461, Faculté de Pharmacie Paris-XI, Châtenay-Malabry, france. | lld:pubmed |
| pubmed-article:11334882 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11334882 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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