| pubmed-article:11333358 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11333358 | lifeskim:mentions | umls-concept:C0086418 | lld:lifeskim |
| pubmed-article:11333358 | lifeskim:mentions | umls-concept:C0006104 | lld:lifeskim |
| pubmed-article:11333358 | lifeskim:mentions | umls-concept:C0682708 | lld:lifeskim |
| pubmed-article:11333358 | lifeskim:mentions | umls-concept:C0007589 | lld:lifeskim |
| pubmed-article:11333358 | lifeskim:mentions | umls-concept:C0178666 | lld:lifeskim |
| pubmed-article:11333358 | lifeskim:mentions | umls-concept:C0556636 | lld:lifeskim |
| pubmed-article:11333358 | lifeskim:mentions | umls-concept:C1511938 | lld:lifeskim |
| pubmed-article:11333358 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11333358 | pubmed:dateCreated | 2001-5-2 | lld:pubmed |
| pubmed-article:11333358 | pubmed:abstractText | Localized 1H nuclear magnetic resonance spectroscopy has been applied to determine human brain gray matter and white matter glucose transport kinetics by measuring the steady-state glucose concentration under normoglycemia and two levels of hyperglycemia. Nuclear magnetic resonance spectroscopic measurements were simultaneously performed on three 12-mL volumes, containing predominantly gray or white matter. The exact volume compositions were determined from quantitative T1 relaxation magnetic resonance images. The absolute brain glucose concentration as a function of the plasma glucose level was fitted with two kinetic transport models, based on standard (irreversible) or reversible Michaelis-Menten kinetics. The steady-state brain glucose levels were similar for cerebral gray and white matter, although the white matter levels were consistently 15% to 20% higher. The ratio of the maximum glucose transport rate, V(max), to the cerebral metabolic utilization rate of glucose, CMR(Glc), was 3.2 +/- 0.10 and 3.9 +/- 0.15 for gray matter and white matter using the standard transport model and 1.8 +/- 0.10 and 2.2 +/- 0.12 for gray matter and white matter using the reversible transport model. The Michaelis-Menten constant K(m) was 6.2 +/- 0.85 and 7.3 +/- 1.1 mmol/L for gray matter and white matter in the standard model and 1.1 +/- 0.66 and 1.7 +/- 0.88 mmol/L in the reversible model. Taking into account the threefold lower rate of CMR(Glc) in white matter, this finding suggests that blood--brain barrier glucose transport activity is lower by a similar amount in white matter. The regulation of glucose transport activity at the blood--brain barrier may be an important mechanism for maintaining glucose homeostasis throughout the cerebral cortex. | lld:pubmed |
| pubmed-article:11333358 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11333358 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11333358 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11333358 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11333358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11333358 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11333358 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11333358 | pubmed:month | May | lld:pubmed |
| pubmed-article:11333358 | pubmed:issn | 0271-678X | lld:pubmed |
| pubmed-article:11333358 | pubmed:author | pubmed-author:BrownPP | lld:pubmed |
| pubmed-article:11333358 | pubmed:author | pubmed-author:LeeJ HJH | lld:pubmed |
| pubmed-article:11333358 | pubmed:author | pubmed-author:RothmanD LDL | lld:pubmed |
| pubmed-article:11333358 | pubmed:author | pubmed-author:NovotnyE JEJ | lld:pubmed |
| pubmed-article:11333358 | pubmed:author | pubmed-author:HetheringtonH... | lld:pubmed |
| pubmed-article:11333358 | pubmed:author | pubmed-author:PanJ WJW | lld:pubmed |
| pubmed-article:11333358 | pubmed:author | pubmed-author:TelangFF | lld:pubmed |
| pubmed-article:11333358 | pubmed:author | pubmed-author:de GraafR ARA | lld:pubmed |
| pubmed-article:11333358 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11333358 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:11333358 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11333358 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11333358 | pubmed:pagination | 483-92 | lld:pubmed |
| pubmed-article:11333358 | pubmed:dateRevised | 2007-11-14 | lld:pubmed |
| pubmed-article:11333358 | pubmed:meshHeading | pubmed-meshheading:11333358... | lld:pubmed |
| pubmed-article:11333358 | pubmed:meshHeading | pubmed-meshheading:11333358... | lld:pubmed |
| pubmed-article:11333358 | pubmed:meshHeading | pubmed-meshheading:11333358... | lld:pubmed |
| pubmed-article:11333358 | pubmed:meshHeading | pubmed-meshheading:11333358... | lld:pubmed |
| pubmed-article:11333358 | pubmed:meshHeading | pubmed-meshheading:11333358... | lld:pubmed |
| pubmed-article:11333358 | pubmed:meshHeading | pubmed-meshheading:11333358... | lld:pubmed |
| pubmed-article:11333358 | pubmed:meshHeading | pubmed-meshheading:11333358... | lld:pubmed |
| pubmed-article:11333358 | pubmed:meshHeading | pubmed-meshheading:11333358... | lld:pubmed |
| pubmed-article:11333358 | pubmed:meshHeading | pubmed-meshheading:11333358... | lld:pubmed |
| pubmed-article:11333358 | pubmed:meshHeading | pubmed-meshheading:11333358... | lld:pubmed |
| pubmed-article:11333358 | pubmed:meshHeading | pubmed-meshheading:11333358... | lld:pubmed |
| pubmed-article:11333358 | pubmed:meshHeading | pubmed-meshheading:11333358... | lld:pubmed |
| pubmed-article:11333358 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11333358 | pubmed:articleTitle | Differentiation of glucose transport in human brain gray and white matter. | lld:pubmed |
| pubmed-article:11333358 | pubmed:affiliation | Department of Radiology, Yale University, School of Medicine, New Haven, Connecticut 06520-8043, USA. | lld:pubmed |
| pubmed-article:11333358 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11333358 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11333358 | pubmed:publicationType | Research Support, U.S. Gov't, Non-P.H.S. | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11333358 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11333358 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11333358 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11333358 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11333358 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11333358 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11333358 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11333358 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11333358 | lld:pubmed |
| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11333358 | lld:pubmed |
