| pubmed-article:11333227 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11333227 | lifeskim:mentions | umls-concept:C0036025 | lld:lifeskim |
| pubmed-article:11333227 | lifeskim:mentions | umls-concept:C0205147 | lld:lifeskim |
| pubmed-article:11333227 | pubmed:issue | 1 | lld:pubmed |
| pubmed-article:11333227 | pubmed:dateCreated | 2001-5-2 | lld:pubmed |
| pubmed-article:11333227 | pubmed:abstractText | Saccharomyces cerevisiae subtelomeric repeats contain silencing elements such as the core X sequence, which is present at all chromosome ends. When transplaced at HML, core X can enhance the action of a distant silencer without acting as a silencer on its own, thus fulfilling the functional definition of a protosilencer. Here we show that an ACS motif and an Abf1p-binding site participate in the silencing capacity of core X and that their effects are additive. In addition, in a variety of settings, core X was found to bring about substantial gene repression only when a low level of silencing was already detectable in its absence. Adjoining an X-STAR sequence, which naturally abuts core X in subtelomeric regions, did not improve the silencing capacity of core X. We propose that protosilencers play a major role in a variety of silencing phenomena, as is the case for core X, which acts as a silencing relay, prolonging silencing propagation away from telomeres. | lld:pubmed |
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| pubmed-article:11333227 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11333227 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11333227 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11333227 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11333227 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11333227 | pubmed:month | May | lld:pubmed |
| pubmed-article:11333227 | pubmed:issn | 0016-6731 | lld:pubmed |
| pubmed-article:11333227 | pubmed:author | pubmed-author:FAYE LEL | lld:pubmed |
| pubmed-article:11333227 | pubmed:author | pubmed-author:FourelGG | lld:pubmed |
| pubmed-article:11333227 | pubmed:author | pubmed-author:LebrunEE | lld:pubmed |
| pubmed-article:11333227 | pubmed:author | pubmed-author:GilsonEE | lld:pubmed |
| pubmed-article:11333227 | pubmed:author | pubmed-author:RevardelEE | lld:pubmed |
| pubmed-article:11333227 | pubmed:author | pubmed-author:BoscheronCC | lld:pubmed |
| pubmed-article:11333227 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11333227 | pubmed:volume | 158 | lld:pubmed |
| pubmed-article:11333227 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11333227 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11333227 | pubmed:pagination | 167-76 | lld:pubmed |
| pubmed-article:11333227 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11333227 | pubmed:meshHeading | pubmed-meshheading:11333227... | lld:pubmed |
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| pubmed-article:11333227 | pubmed:meshHeading | pubmed-meshheading:11333227... | lld:pubmed |
| pubmed-article:11333227 | pubmed:meshHeading | pubmed-meshheading:11333227... | lld:pubmed |
| pubmed-article:11333227 | pubmed:meshHeading | pubmed-meshheading:11333227... | lld:pubmed |
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| pubmed-article:11333227 | pubmed:meshHeading | pubmed-meshheading:11333227... | lld:pubmed |
| pubmed-article:11333227 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11333227 | pubmed:articleTitle | Protosilencers in Saccharomyces cerevisiae subtelomeric regions. | lld:pubmed |
| pubmed-article:11333227 | pubmed:affiliation | Laboratoire de Biologie Moléculaire et Cellulaire, UMR5665 CNRS/ENSL, Ecole Normale Supérieure de Lyon, 46 Allée d'Italie, 69364 Lyon Cedex 07, France. | lld:pubmed |
| pubmed-article:11333227 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11333227 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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