Linked Life Data

11332893

Source:http://linkedlifedata.com/resource/pubmed/id/11332893

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pubmed-article:11332893pubmed:abstractTextHexylester of 5-aminolevulinic acid (hALA) has been considered as an alternative to 5-aminolevulinic acid (ALA) for the treatment of malignancies of different origin. The present study addresses the ALA and hALA-induced PpIX pharmacokinetic profile using rat bladder carcinoma cells (AY27). The total PpIX content measured spectrofluorimetrically after extraction procedure at the end of 2 h incubation was at least 1.5-fold greater with hALA compared to ALA despite the difference in concentration of several orders between the two compounds (1 or 5 mM ALA and 5 or 10 x 10(-3) mM hALA). Considerable PpIX efflux was detected in the extracellular medium at the end of the incubation. With 5 mM ALA and 10 x 10(-3) mM hALA, PpIX build-up was continued beyond the incubation period pointing out to enzyme saturation in the biosynthetic pathway or/and the constitution of ALA reserve. Red laser light (lambda=630 nm) irradiation of AY27 cells after 2 h incubation with increasing ALA or hALA concentrations resulted in a nearly equal photocytotoxicity.lld:pubmed
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pubmed-article:11332893pubmed:dateRevised2007-7-23lld:pubmed
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pubmed-article:11332893pubmed:articleTitleBiosynthesis and photodynamic efficacy of protoporphyrin IX (PpIX) generated by 5-aminolevulinic acid (ALA) or its hexylester (hALA) in rat bladder carcinoma cells.lld:pubmed
pubmed-article:11332893pubmed:affiliationLaboratoire d' Hématologie, Physiologie et Biologie Cellulaire, Faculté de Pharmacie, Nancy, France. cosserat@pharma.u-nancy.frlld:pubmed
pubmed-article:11332893pubmed:publicationTypeJournal Articlelld:pubmed
pubmed-article:11332893pubmed:publicationTypeResearch Support, Non-U.S. Gov'tlld:pubmed
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