pubmed-article:11329125 | rdf:type | pubmed:Citation | lld:pubmed |
pubmed-article:11329125 | lifeskim:mentions | umls-concept:C0025914 | lld:lifeskim |
pubmed-article:11329125 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
pubmed-article:11329125 | lifeskim:mentions | umls-concept:C0028936 | lld:lifeskim |
pubmed-article:11329125 | lifeskim:mentions | umls-concept:C0815005 | lld:lifeskim |
pubmed-article:11329125 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
pubmed-article:11329125 | pubmed:issue | 1 | lld:pubmed |
pubmed-article:11329125 | pubmed:dateCreated | 2001-4-30 | lld:pubmed |
pubmed-article:11329125 | pubmed:abstractText | Radial glia are critical for cell migration and lamination of the cortex. In most developing cortical structures, radial glia, as their name suggests, extend processes from the ventricle to the pia in regular parallel arrangements. However, immunohistochemical labeling from several laboratories suggests that radial glia have a more branched morphology in the olfactory bulb. To investigate the morphology of radial glia in the mouse olfactory bulb we (1) labeled radial glia and olfactory receptor neuron axons at 24-hour intervals by immunohistochemistry; and (2) developed a novel method of generating and applying "nanocrystals" of 1,1'-dioctadecyl-3,3,3',3'- tetramethylindocarbocyanine perchlorate (DiI) to the ventricle surface such that the processes of single olfactory bulb radial glia are labeled in the embryonic olfactory bulb. We examined the structure and interactions of radial glia with ingrowing olfactory receptor neuron (ORN) axons in late embryonic olfactory bulb development. These results showed that olfactory bulb radial glia do not form straight parallel structures as do radial glia in the neocortex but rather have a convoluted trajectory from the ventricle to the bulb surface. Moreover, olfactory bulb radial glia consistently extend tangential branches at the level of the internal plexiform layer. Beginning at embryonic day 17.5, two types of radial glia can be distinguished: type I radial glia have a process that extends from the ventricle into the glomerular layer. These apical processes form highly restricted tufts, or "glial glomeruli" at the same time that ORN axons are forming "axonal glomeruli." In type II radial glia the apical process does not enter the glomerular layer but instead ramifies within the external plexiform layer. The tight spatiotemporal relationship between the glomerulization of radial glia processes and ORN axons during development suggest that radial glia processes could play a role in the formation and/or stabilization of mammalian glomeruli. | lld:pubmed |
pubmed-article:11329125 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11329125 | pubmed:language | eng | lld:pubmed |
pubmed-article:11329125 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
pubmed-article:11329125 | pubmed:citationSubset | IM | lld:pubmed |
pubmed-article:11329125 | pubmed:status | MEDLINE | lld:pubmed |
pubmed-article:11329125 | pubmed:month | May | lld:pubmed |
pubmed-article:11329125 | pubmed:issn | 0021-9967 | lld:pubmed |
pubmed-article:11329125 | pubmed:author | pubmed-author:ShipleyM TMT | lld:pubmed |
pubmed-article:11329125 | pubmed:author | pubmed-author:PucheA CAC | lld:pubmed |
pubmed-article:11329125 | pubmed:copyrightInfo | Copyright 2001 Wiley-Liss, Inc. | lld:pubmed |
pubmed-article:11329125 | pubmed:issnType | Print | lld:pubmed |
pubmed-article:11329125 | pubmed:day | 21 | lld:pubmed |
pubmed-article:11329125 | pubmed:volume | 434 | lld:pubmed |
pubmed-article:11329125 | pubmed:owner | NLM | lld:pubmed |
pubmed-article:11329125 | pubmed:authorsComplete | Y | lld:pubmed |
pubmed-article:11329125 | pubmed:pagination | 1-12 | lld:pubmed |
pubmed-article:11329125 | pubmed:dateRevised | 2008-11-21 | lld:pubmed |
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pubmed-article:11329125 | pubmed:meshHeading | pubmed-meshheading:11329125... | lld:pubmed |
pubmed-article:11329125 | pubmed:year | 2001 | lld:pubmed |
pubmed-article:11329125 | pubmed:articleTitle | Radial glia development in the mouse olfactory bulb. | lld:pubmed |
pubmed-article:11329125 | pubmed:affiliation | Department of Anatomy and Neurobiology, Program in Neuroscience, The University of Maryland, School of Medicine, Baltimore, Maryland 21201, USA. apuche@umaryland.edu | lld:pubmed |
pubmed-article:11329125 | pubmed:publicationType | Journal Article | lld:pubmed |
pubmed-article:11329125 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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entrez-gene:107980 | entrezgene:pubmed | pubmed-article:11329125 | lld:entrezgene |
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