| pubmed-article:11327577 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11327577 | lifeskim:mentions | umls-concept:C1513016 | lld:lifeskim |
| pubmed-article:11327577 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11327577 | pubmed:dateCreated | 2001-4-30 | lld:pubmed |
| pubmed-article:11327577 | pubmed:abstractText | Potent and selective inhibition of matrix metalloproteinases was demonstrated for a series of sulfonamide-based hydroxamic acids. The design of the heterocyclic sulfonamides incorporates a six- or seven-member central ring with a P2' substituent that can be modified. Binding interactions of this substituent at the S2' site are believed to contribute to high inhibitory potency against stromelysin, collagenase-3 and gelatinases A and B, and to provide selectivity against collagenase-1 and matrilysin. An X-ray structure of a stromelysin inhibitor complex was obtained to provide insights into the SAR and selectivity trends observed for the series. | lld:pubmed |
| pubmed-article:11327577 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11327577 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11327577 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11327577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11327577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11327577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11327577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11327577 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
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| pubmed-article:11327577 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11327577 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11327577 | pubmed:issn | 0960-894X | lld:pubmed |
| pubmed-article:11327577 | pubmed:author | pubmed-author:KAON CNC | lld:pubmed |
| pubmed-article:11327577 | pubmed:author | pubmed-author:HyndB ABA | lld:pubmed |
| pubmed-article:11327577 | pubmed:author | pubmed-author:WilliamsL ELE | lld:pubmed |
| pubmed-article:11327577 | pubmed:author | pubmed-author:MielingG EGE | lld:pubmed |
| pubmed-article:11327577 | pubmed:author | pubmed-author:EYWW | lld:pubmed |
| pubmed-article:11327577 | pubmed:author | pubmed-author:TaiwoY OYO | lld:pubmed |
| pubmed-article:11327577 | pubmed:author | pubmed-author:JanuszM JMJ | lld:pubmed |
| pubmed-article:11327577 | pubmed:author | pubmed-author:HsiehL CLC | lld:pubmed |
| pubmed-article:11327577 | pubmed:author | pubmed-author:PikusJJ | lld:pubmed |
| pubmed-article:11327577 | pubmed:author | pubmed-author:AlmsteadN GNG | lld:pubmed |
| pubmed-article:11327577 | pubmed:author | pubmed-author:NatchusM GMG | lld:pubmed |
| pubmed-article:11327577 | pubmed:author | pubmed-author:DunhamK MKM | lld:pubmed |
| pubmed-article:11327577 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11327577 | pubmed:day | 23 | lld:pubmed |
| pubmed-article:11327577 | pubmed:volume | 11 | lld:pubmed |
| pubmed-article:11327577 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11327577 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11327577 | pubmed:pagination | 1009-13 | lld:pubmed |
| pubmed-article:11327577 | pubmed:dateRevised | 2006-11-15 | lld:pubmed |
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| pubmed-article:11327577 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11327577 | pubmed:articleTitle | Heterocycle-based MMP inhibitors with P2' substituents. | lld:pubmed |
| pubmed-article:11327577 | pubmed:affiliation | Procter and Gamble Pharmaceuticals, Health Care Research Center, Mason, OH 45040, USA. spikul@avalonrx.com | lld:pubmed |
| pubmed-article:11327577 | pubmed:publicationType | Journal Article | lld:pubmed |
| http://linkedlifedata.com/r... | http://linkedlifedata.com/r... | pubmed-article:11327577 | lld:chembl |
| entrez-gene:4314 | entrezgene:pubmed | pubmed-article:11327577 | lld:entrezgene |
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