| pubmed-article:11313987 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11313987 | lifeskim:mentions | umls-concept:C0031727 | lld:lifeskim |
| pubmed-article:11313987 | lifeskim:mentions | umls-concept:C0184512 | lld:lifeskim |
| pubmed-article:11313987 | lifeskim:mentions | umls-concept:C0332281 | lld:lifeskim |
| pubmed-article:11313987 | lifeskim:mentions | umls-concept:C1413289 | lld:lifeskim |
| pubmed-article:11313987 | lifeskim:mentions | umls-concept:C1264638 | lld:lifeskim |
| pubmed-article:11313987 | lifeskim:mentions | umls-concept:C0243102 | lld:lifeskim |
| pubmed-article:11313987 | lifeskim:mentions | umls-concept:C1611475 | lld:lifeskim |
| pubmed-article:11313987 | pubmed:issue | 5 | lld:pubmed |
| pubmed-article:11313987 | pubmed:dateCreated | 2001-4-23 | lld:pubmed |
| pubmed-article:11313987 | pubmed:abstractText | Cyclin C belongs to the cyclin family of proteins that control cell cycle transitions through activation of specific catalytic subunits, the cyclin-dependent kinases (CDKs). However, there is as yet no evidence for any role of cyclin C and its partner, cdk8, in cell cycle regulation. Rather, the cyclin C-cdk8 complex was found associated with the RNA polymerase II transcription machinery. The periodic degradation of bona fide cyclins is crucial for cell-cycle progression and depends on the catalytic activity of the associated CDK. Here we show that endogenous cyclin C protein is quite stable with a half-life of 4 h. In contrast, exogenously expressed cyclin C is very unstable (half-life 15 min) and degraded by the ubiquitin-proteasome pathway. Co-expression with its associated cdk, however, strongly stabilizes cyclin C and results in a protein half-life near that of endogenous cyclin C. In stark contrast to data reported for other members of the cyclin family, both catalytically active and inactive cdk8 induce cyclin C stabilization. Moreover, this stabilization is accompanied in both cases by phosphorylation of the cyclin, which is not detectable when unstable. Our results indicate that cyclin C has apparently diverged from other cyclins in the regulation of its stability by its CDK partner. | lld:pubmed |
| pubmed-article:11313987 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11313987 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11313987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313987 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11313987 | pubmed:month | Feb | lld:pubmed |
| pubmed-article:11313987 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:11313987 | pubmed:author | pubmed-author:PietteJJ | lld:pubmed |
| pubmed-article:11313987 | pubmed:author | pubmed-author:PiechaczykMM | lld:pubmed |
| pubmed-article:11313987 | pubmed:author | pubmed-author:Jariel-Encont... | lld:pubmed |
| pubmed-article:11313987 | pubmed:author | pubmed-author:BaretteCC | lld:pubmed |
| pubmed-article:11313987 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11313987 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11313987 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:11313987 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11313987 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11313987 | pubmed:pagination | 551-62 | lld:pubmed |
| pubmed-article:11313987 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11313987 | pubmed:meshHeading | pubmed-meshheading:11313987... | lld:pubmed |
| pubmed-article:11313987 | pubmed:meshHeading | pubmed-meshheading:11313987... | lld:pubmed |
| pubmed-article:11313987 | pubmed:meshHeading | pubmed-meshheading:11313987... | lld:pubmed |
| pubmed-article:11313987 | pubmed:meshHeading | pubmed-meshheading:11313987... | lld:pubmed |
| pubmed-article:11313987 | pubmed:meshHeading | pubmed-meshheading:11313987... | lld:pubmed |
| pubmed-article:11313987 | pubmed:meshHeading | pubmed-meshheading:11313987... | lld:pubmed |
| pubmed-article:11313987 | pubmed:meshHeading | pubmed-meshheading:11313987... | lld:pubmed |
| pubmed-article:11313987 | pubmed:meshHeading | pubmed-meshheading:11313987... | lld:pubmed |
| pubmed-article:11313987 | pubmed:meshHeading | pubmed-meshheading:11313987... | lld:pubmed |
| pubmed-article:11313987 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11313987 | pubmed:articleTitle | Human cyclin C protein is stabilized by its associated kinase cdk8, independently of its catalytic activity. | lld:pubmed |
| pubmed-article:11313987 | pubmed:affiliation | Institut de Genetique Moleculaire de Montpellier, CNRS UMR 5535, IFR24, 1919, route de Mende, 34293 Montpellier Cedex 5, France. | lld:pubmed |
| pubmed-article:11313987 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11313987 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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| http://linkedlifedata.com/r... | pubmed:referesTo | pubmed-article:11313987 | lld:pubmed |
