| pubmed-article:11313946 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11313946 | lifeskim:mentions | umls-concept:C0035647 | lld:lifeskim |
| pubmed-article:11313946 | lifeskim:mentions | umls-concept:C0007595 | lld:lifeskim |
| pubmed-article:11313946 | lifeskim:mentions | umls-concept:C0288472 | lld:lifeskim |
| pubmed-article:11313946 | lifeskim:mentions | umls-concept:C0249197 | lld:lifeskim |
| pubmed-article:11313946 | lifeskim:mentions | umls-concept:C1420626 | lld:lifeskim |
| pubmed-article:11313946 | lifeskim:mentions | umls-concept:C0920532 | lld:lifeskim |
| pubmed-article:11313946 | lifeskim:mentions | umls-concept:C0851285 | lld:lifeskim |
| pubmed-article:11313946 | lifeskim:mentions | umls-concept:C0679622 | lld:lifeskim |
| pubmed-article:11313946 | lifeskim:mentions | umls-concept:C0205314 | lld:lifeskim |
| pubmed-article:11313946 | pubmed:issue | 2 | lld:pubmed |
| pubmed-article:11313946 | pubmed:dateCreated | 2001-4-23 | lld:pubmed |
| pubmed-article:11313946 | pubmed:databankReference | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:abstractText | Here, we report the identification and characterization of a new member of the RalGDS-family, which is widely expressed and interacts strongly and selectively with the GTP-bound forms of M-Ras and p21 Ras. This Ras pathway modulator (RPM), also termed RGL3, exhibited Ras-binding and catalytic domains typical of the RalGDS-family of guanine nucleotide exchange factors, and was most similar to Rlf (RalGDS-like factor), but was distinguished by a unique proline-rich region with multiple candidate SH3-domain binding sites. RPM/RGL3 resembled AF-6 and Nore1 in interacting strongly with constitutively active M-Ras and p21 Ras. In contrast to Rlf, transiently expressed RPM/RGL3 did not activate an Elk-1-inducible reporter gene alone or in combination with activated p21 Ras, but strongly inhibited induction of this reporter gene by co-expression of activated H-Ras or MEKK-1. This inhibitory effect was independent of the Ras binding domain and required a second signal provided by p21 Ras or MEKK-1, but not Raf-1 or M-Ras. Expression of RPM/RGL3 also strongly inhibited cell growth of fibroblasts transformed by an activated Src Y527F. Thus, RPM/RGL3 is a novel potential effector of both p21 Ras and M-Ras with the novel function of negatively regulating Elk-1-dependent gene induction downstream of p21 Ras or MEKK-1. | lld:pubmed |
| pubmed-article:11313946 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11313946 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313946 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11313946 | pubmed:month | Jan | lld:pubmed |
| pubmed-article:11313946 | pubmed:issn | 0950-9232 | lld:pubmed |
| pubmed-article:11313946 | pubmed:author | pubmed-author:KnausMM | lld:pubmed |
| pubmed-article:11313946 | pubmed:author | pubmed-author:SchraderJ WJW | lld:pubmed |
| pubmed-article:11313946 | pubmed:author | pubmed-author:WielerJ SJS | lld:pubmed |
| pubmed-article:11313946 | pubmed:author | pubmed-author:KorherrCC | lld:pubmed |
| pubmed-article:11313946 | pubmed:author | pubmed-author:EhrhardtG RGR | lld:pubmed |
| pubmed-article:11313946 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11313946 | pubmed:day | 11 | lld:pubmed |
| pubmed-article:11313946 | pubmed:volume | 20 | lld:pubmed |
| pubmed-article:11313946 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11313946 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11313946 | pubmed:pagination | 188-97 | lld:pubmed |
| pubmed-article:11313946 | pubmed:dateRevised | 2011-11-2 | lld:pubmed |
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| pubmed-article:11313946 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11313946 | pubmed:articleTitle | A novel potential effector of M-Ras and p21 Ras negatively regulates p21 Ras-mediated gene induction and cell growth. | lld:pubmed |
| pubmed-article:11313946 | pubmed:affiliation | The Biomedical Research Centre, 2222 Health Sciences Mall, University of British Columbia, Vancouver BC, V6T 1Z3 Canada. | lld:pubmed |
| pubmed-article:11313946 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11313946 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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