| pubmed-article:11313485 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11313485 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11313485 | lifeskim:mentions | umls-concept:C0292369 | lld:lifeskim |
| pubmed-article:11313485 | lifeskim:mentions | umls-concept:C1326912 | lld:lifeskim |
| pubmed-article:11313485 | lifeskim:mentions | umls-concept:C0812273 | lld:lifeskim |
| pubmed-article:11313485 | lifeskim:mentions | umls-concept:C0181586 | lld:lifeskim |
| pubmed-article:11313485 | lifeskim:mentions | umls-concept:C0332453 | lld:lifeskim |
| pubmed-article:11313485 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11313485 | pubmed:dateCreated | 2001-4-23 | lld:pubmed |
| pubmed-article:11313485 | pubmed:abstractText | SNF5/INI1 is a component of the ATP-dependent chromatin remodeling enzyme family SWI/SNF. Germ line mutations of INI1 have been identified in children with brain and renal rhabdoid tumors, indicating that INI1 is a tumor suppressor. Here we report that disruption of Ini1 expression in mice results in early embryonic lethality. Ini1-null embryos die between 3.5 and 5.5 days postcoitum, and Ini1-null blastocysts fail to hatch, form the trophectoderm, or expand the inner cell mass when cultured in vitro. Furthermore, we report that approximately 15% of Ini1-heterozygous mice present with tumors, mostly undifferentiated or poorly differentiated sarcomas. Tumor formation is associated with a loss of heterozygocity at the Ini1 locus, characterizing Ini1 as a tumor suppressor in mice. Thus, Ini1 is essential for embryo viability and for repression of oncogenesis in the adult organism. | lld:pubmed |
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| pubmed-article:11313485 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11313485 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313485 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11313485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313485 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313485 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11313485 | pubmed:month | May | lld:pubmed |
| pubmed-article:11313485 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:11313485 | pubmed:author | pubmed-author:SmithT WTW | lld:pubmed |
| pubmed-article:11313485 | pubmed:author | pubmed-author:WebsterWW | lld:pubmed |
| pubmed-article:11313485 | pubmed:author | pubmed-author:JonesS NSN | lld:pubmed |
| pubmed-article:11313485 | pubmed:author | pubmed-author:ImbalzanoA... | lld:pubmed |
| pubmed-article:11313485 | pubmed:author | pubmed-author:SandsA TAT | lld:pubmed |
| pubmed-article:11313485 | pubmed:author | pubmed-author:TurleyR HRH | lld:pubmed |
| pubmed-article:11313485 | pubmed:author | pubmed-author:ZambrowiczB... | lld:pubmed |
| pubmed-article:11313485 | pubmed:author | pubmed-author:GuidiC JCJ | lld:pubmed |
| pubmed-article:11313485 | pubmed:author | pubmed-author:DemersD ADA | lld:pubmed |
| pubmed-article:11313485 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11313485 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:11313485 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11313485 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11313485 | pubmed:pagination | 3598-603 | lld:pubmed |
| pubmed-article:11313485 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
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| pubmed-article:11313485 | pubmed:meshHeading | pubmed-meshheading:11313485... | lld:pubmed |
| pubmed-article:11313485 | pubmed:year | 2001 | lld:pubmed |
