| pubmed-article:11313481 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11313481 | lifeskim:mentions | umls-concept:C0035820 | lld:lifeskim |
| pubmed-article:11313481 | lifeskim:mentions | umls-concept:C0966147 | lld:lifeskim |
| pubmed-article:11313481 | lifeskim:mentions | umls-concept:C0741847 | lld:lifeskim |
| pubmed-article:11313481 | pubmed:issue | 10 | lld:pubmed |
| pubmed-article:11313481 | pubmed:dateCreated | 2001-4-23 | lld:pubmed |
| pubmed-article:11313481 | pubmed:abstractText | UV light-induced DNA lesions block the normal replication machinery. Eukaryotic cells possess DNA polymerase eta (Poleta), which has the ability to replicate past a cis-syn thymine-thymine (TT) dimer efficiently and accurately, and mutations in human Poleta result in the cancer-prone syndrome, the variant form of xeroderma pigmentosum. Here, we test Poleta for its ability to bypass a (6-4) TT lesion which distorts the DNA helix to a much greater extent than a cis-syn TT dimer. Opposite the 3' T of a (6-4) TT photoproduct, both yeast and human Poleta preferentially insert a G residue, but they are unable to extend from the inserted nucleotide. DNA Polzeta, essential for UV induced mutagenesis, efficiently extends from the G residue inserted opposite the 3' T of the (6-4) TT lesion by Poleta, and Polzeta inserts the correct nucleotide A opposite the 5' T of the lesion. Thus, the efficient bypass of the (6-4) TT photoproduct is achieved by the combined action of Poleta and Polzeta, wherein Poleta inserts a nucleotide opposite the 3' T of the lesion and Polzeta extends from it. These biochemical observations are in concert with genetic studies in yeast indicating that mutations occur predominantly at the 3' T of the (6-4) TT photoproduct and that these mutations frequently exhibit a 3' T-->C change that would result from the insertion of a G opposite the 3' T of the (6-4) TT lesion. | lld:pubmed |
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| pubmed-article:11313481 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11313481 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313481 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11313481 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11313481 | pubmed:month | May | lld:pubmed |
| pubmed-article:11313481 | pubmed:issn | 0270-7306 | lld:pubmed |
| pubmed-article:11313481 | pubmed:author | pubmed-author:PrakashLL | lld:pubmed |
| pubmed-article:11313481 | pubmed:author | pubmed-author:PrakashSS | lld:pubmed |
| pubmed-article:11313481 | pubmed:author | pubmed-author:JohnsonR ERE | lld:pubmed |
| pubmed-article:11313481 | pubmed:author | pubmed-author:HaracskaLL | lld:pubmed |
| pubmed-article:11313481 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11313481 | pubmed:volume | 21 | lld:pubmed |
| pubmed-article:11313481 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11313481 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11313481 | pubmed:pagination | 3558-63 | lld:pubmed |
| pubmed-article:11313481 | pubmed:dateRevised | 2009-11-18 | lld:pubmed |
| pubmed-article:11313481 | pubmed:meshHeading | pubmed-meshheading:11313481... | lld:pubmed |
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| pubmed-article:11313481 | pubmed:meshHeading | pubmed-meshheading:11313481... | lld:pubmed |
| pubmed-article:11313481 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11313481 | pubmed:articleTitle | Role of DNA polymerase zeta in the bypass of a (6-4) TT photoproduct. | lld:pubmed |
| pubmed-article:11313481 | pubmed:affiliation | Sealy Center for Molecular Science, University of Texas Medical Branch, Galveston, Texas 77555-1061, USA. | lld:pubmed |
| pubmed-article:11313481 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11313481 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11313481 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
| entrez-gene:854667 | entrezgene:pubmed | pubmed-article:11313481 | lld:entrezgene |
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