| pubmed-article:11313416 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11313416 | lifeskim:mentions | umls-concept:C0017355 | lld:lifeskim |
| pubmed-article:11313416 | lifeskim:mentions | umls-concept:C0003320 | lld:lifeskim |
| pubmed-article:11313416 | lifeskim:mentions | umls-concept:C0332261 | lld:lifeskim |
| pubmed-article:11313416 | lifeskim:mentions | umls-concept:C0449450 | lld:lifeskim |
| pubmed-article:11313416 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:11313416 | lifeskim:mentions | umls-concept:C1272745 | lld:lifeskim |
| pubmed-article:11313416 | lifeskim:mentions | umls-concept:C2349090 | lld:lifeskim |
| pubmed-article:11313416 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11313416 | pubmed:dateCreated | 2001-4-23 | lld:pubmed |
| pubmed-article:11313416 | pubmed:abstractText | The potency of naked DNA vaccines is limited by their inability to amplify and spread in vivo. VP22, a HSV-1 protein, has demonstrated the remarkable property of intercellular transport and may thus provide a unique approach for enhancing vaccine potency. Therefore, we created a novel fusion of VP22 with a model Ag, human papillomavirus type 16 E7, in a DNA vaccine that generated enhanced spreading and MHC class I presentation of AG: These properties led to a dramatic increase in the number of E7-specific CD8(+) T cell precursors in vaccinated mice (around 50-fold) and converted a less effective DNA vaccine into one with significant potency against E7-expressing tumors. In comparison, nonspreading VP22(1-267) mutants failed to enhance vaccine potency. Our data indicated that the potency of DNA vaccines may be dramatically improved through intercellular spreading and enhanced MHC class I presentation of Ag. | lld:pubmed |
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| pubmed-article:11313416 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313416 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11313416 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11313416 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11313416 | pubmed:month | May | lld:pubmed |
| pubmed-article:11313416 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11313416 | pubmed:author | pubmed-author:ChaiC YCY | lld:pubmed |
| pubmed-article:11313416 | pubmed:author | pubmed-author:FOXJ TJT | lld:pubmed |
| pubmed-article:11313416 | pubmed:author | pubmed-author:?ZZ | lld:pubmed |
| pubmed-article:11313416 | pubmed:author | pubmed-author:LinkAA | lld:pubmed |
| pubmed-article:11313416 | pubmed:author | pubmed-author:WuT CTC | lld:pubmed |
| pubmed-article:11313416 | pubmed:author | pubmed-author:ChengW FWF | lld:pubmed |
| pubmed-article:11313416 | pubmed:author | pubmed-author:LEVYJ IJI | lld:pubmed |
| pubmed-article:11313416 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11313416 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11313416 | pubmed:volume | 166 | lld:pubmed |
| pubmed-article:11313416 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11313416 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11313416 | pubmed:pagination | 5733-40 | lld:pubmed |
| pubmed-article:11313416 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11313416 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11313416 | pubmed:articleTitle | Improving vaccine potency through intercellular spreading and enhanced MHC class I presentation of antigen. | lld:pubmed |
| pubmed-article:11313416 | pubmed:affiliation | Department of Pathology, Johns Hopkins Medical Institutions, Baltimore, MD 21205, USA. | lld:pubmed |
| pubmed-article:11313416 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11313416 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11313416 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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