| pubmed-article:11313391 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11313391 | lifeskim:mentions | umls-concept:C0026724 | lld:lifeskim |
| pubmed-article:11313391 | lifeskim:mentions | umls-concept:C0024264 | lld:lifeskim |
| pubmed-article:11313391 | lifeskim:mentions | umls-concept:C0205145 | lld:lifeskim |
| pubmed-article:11313391 | lifeskim:mentions | umls-concept:C1882846 | lld:lifeskim |
| pubmed-article:11313391 | lifeskim:mentions | umls-concept:C1881379 | lld:lifeskim |
| pubmed-article:11313391 | pubmed:issue | 9 | lld:pubmed |
| pubmed-article:11313391 | pubmed:dateCreated | 2001-4-23 | lld:pubmed |
| pubmed-article:11313391 | pubmed:abstractText | Development of T cell lineages and the role of the thymus as a source of immature T cells in parotid (PG) and submandibular salivary glands (SMG) were studied in Fischer 344 rats using the Thy-1/CD45RC/RT6 expression model. In addition, the phenotypes of salivary gland lymphocytes were compared with other conventional and extrathymic populations. PG mononuclear cells consisted of T cells (38%), B cells (29%), and NK cells (4%). SMG had 19% T cells, 7% B cells, 37% NK cells, and an unusual population of CD3(-)/RT6(+) cells. In comparison with lymph node (LN), both PG and SMG were enriched in immature (Thy-1(+)) and activated (Thy-1(-)/CD45RC(-)/RT6(-)) T cells. Unchanged percentages of Thy-1(+) T cells in PG and SMG following short-term adult thymectomy indicated that immature salivary gland T cells had an extrathymic source. In contrast, thymectomy eliminated LN recent thymic emigrants. SMG had T cells with characteristics of extrathymic populations, expressing TCRgammadelta(+) (28%), the CD8alphaalpha homodimer (11%), and NKR-P1A (66%). Many SMG T cells expressed integrin alpha(E)beta(7). PG T cells resembled those isolated from LN in respect to TCR and CD8 isoform usage, but were enriched in alpha(E)beta(7)(+) T cells and in NKT cells. Thus, salivary gland mononuclear cells are composed of a variety of subpopulations whose distributions differ between SMG and PG and are distinct from LN. These studies provide a basis for further investigation of regionalization in the mucosal immune network and are relevant to the design of vaccine regimens and intervention during pathological immune processes. | lld:pubmed |
| pubmed-article:11313391 | pubmed:grant | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313391 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11313391 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313391 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11313391 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11313391 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11313391 | pubmed:month | May | lld:pubmed |
| pubmed-article:11313391 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11313391 | pubmed:author | pubmed-author:MontgomeryP... | lld:pubmed |
| pubmed-article:11313391 | pubmed:author | pubmed-author:SkanderaC ACA | lld:pubmed |
| pubmed-article:11313391 | pubmed:author | pubmed-author:O'SullivanN... | lld:pubmed |
| pubmed-article:11313391 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11313391 | pubmed:day | 1 | lld:pubmed |
| pubmed-article:11313391 | pubmed:volume | 166 | lld:pubmed |
| pubmed-article:11313391 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11313391 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11313391 | pubmed:pagination | 5522-9 | lld:pubmed |
| pubmed-article:11313391 | pubmed:dateRevised | 2009-9-7 | lld:pubmed |
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| pubmed-article:11313391 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11313391 | pubmed:articleTitle | Lymphocyte lineages at mucosal effector sites: rat salivary glands. | lld:pubmed |
| pubmed-article:11313391 | pubmed:affiliation | Departments of. Anatomy and Cell Biology and Immunology and Microbiology, Wayne State University School of Medicine, Detroit, MI 48201, USA. nosulliv@med.wayne.edu | lld:pubmed |
| pubmed-article:11313391 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11313391 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
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