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pubmed-article:11312679pubmed:dateCreated2001-4-23lld:pubmed
pubmed-article:11312679pubmed:abstractTextCommercially-available sulforhodamine sulfonyl chlorides contain two isomeric monosulfonyl chlorides. Conjugates of these isomers with amines have different properties because the sulfonamide formed from one isomer can undergo ring-closure to a colorless sultam. This chemistry has been examined for a model conjugate with methylamine and for a bioconjugate with 2'(3')-O-[N-(2-aminoethyl)carbamoyl]ATP. The interaction of each isomer of the latter conjugates with myosin subfragment 1 has been characterized. Significant differences between the two isomers are observed in these interactions.lld:pubmed
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pubmed-article:11312679pubmed:authorpubmed-author:EcclestonJ...lld:pubmed
pubmed-article:11312679pubmed:authorpubmed-author:CorrieJ EJElld:pubmed
pubmed-article:11312679pubmed:authorpubmed-author:DavisC TCTlld:pubmed
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pubmed-article:11312679pubmed:articleTitleChemistry of sulforhodamine--amine conjugates.lld:pubmed
pubmed-article:11312679pubmed:affiliationNational Institute for Medical Research, The Ridgeway, Mill Hill, London NW7 1AA, UK. jcorrie@nimr.mrc.ac.uklld:pubmed
pubmed-article:11312679pubmed:publicationTypeJournal Articlelld:pubmed