| pubmed-article:11309267 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11309267 | lifeskim:mentions | umls-concept:C0012984 | lld:lifeskim |
| pubmed-article:11309267 | lifeskim:mentions | umls-concept:C0038351 | lld:lifeskim |
| pubmed-article:11309267 | lifeskim:mentions | umls-concept:C0036751 | lld:lifeskim |
| pubmed-article:11309267 | lifeskim:mentions | umls-concept:C0597357 | lld:lifeskim |
| pubmed-article:11309267 | lifeskim:mentions | umls-concept:C0086597 | lld:lifeskim |
| pubmed-article:11309267 | lifeskim:mentions | umls-concept:C1533691 | lld:lifeskim |
| pubmed-article:11309267 | lifeskim:mentions | umls-concept:C0681829 | lld:lifeskim |
| pubmed-article:11309267 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:11309267 | lifeskim:mentions | umls-concept:C1627358 | lld:lifeskim |
| pubmed-article:11309267 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11309267 | pubmed:dateCreated | 2001-4-19 | lld:pubmed |
| pubmed-article:11309267 | pubmed:abstractText | We aimed to study 5-HT(4) receptors in canine stomach contractility both in vivo and in vitro. In anaesthetized Beagle dogs, the selective 5-HT(4) receptor agonist prucalopride (i.v.) induced dose-dependent tonic stomach contractions under isobaric conditions, an effect that was antagonized by the selective 5-HT(4) receptor antagonist GR 125487 (10 microg kg(-1), i.v.). Electrical field stimulation (EFS) of corpus longitudinal muscle strips resulted in atropine- and tetrodotoxin-sensitive contractions (L-NOARG (0.1 mM) present in all organ bath solutions). Prucalopride increased these contractions (maximal response after single-dose addition (0.3 microM): 165% of initial value, or after cumulative addition: 188%). In the presence of methysergide (3 microM), 5-HT also increased EFS-contractions (after single-dose addition (0.3 microM): increase to 192%, after cumulative addition: 148%). The selective 5-HT(4) receptor antagonists GR 113808 (0.1 microM) or GR 125487 (10 nM) antagonized the prucalopride (0.3 microM)-induced contraction increments. When EFS-induced contractions were blocked by atropine or tetrodotoxin, prucalopride was ineffective. In the presence of methysergide (3 microM), the contraction increases to 5-HT (0.3 microM) were prevented by GR 113808 (0.1 microM). The prucalopride curve (pEC(50) 7.9) was shifted in parallel to the right by GR 113808 3 nM (pA(2) 9.4). In the presence of methysergide (3 microM), the curve to 5-HT (pEC(50) 8.1) was competitively antagonized by GR 113808, yielding a Schild slope of 0.8+/-0.2 (pK(B) of 9.1 with unit Schild slope). In corpus circular muscle strips, the prucalopride (0.3 microM)-induced augmentation of EFS-contractions (258%) was also prevented by GR 113808 (0.1 microM) (124%). In conclusion, the effects of 5-HT(4) receptor agonists on proximal stomach motor activity in vivo can be explained by an effect on 5-HT(4) receptors on cholinergic nerves within the gastric muscle wall. | lld:pubmed |
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| pubmed-article:11309267 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11309267 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11309267 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11309267 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11309267 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11309267 | pubmed:issn | 0007-1188 | lld:pubmed |
| pubmed-article:11309267 | pubmed:author | pubmed-author:AkkermansL... | lld:pubmed |
| pubmed-article:11309267 | pubmed:author | pubmed-author:LefebvreR ARA | lld:pubmed |
| pubmed-article:11309267 | pubmed:author | pubmed-author:SchuurkesJ... | lld:pubmed |
| pubmed-article:11309267 | pubmed:author | pubmed-author:PrinsN HNH | lld:pubmed |
| pubmed-article:11309267 | pubmed:author | pubmed-author:van Der... | lld:pubmed |
| pubmed-article:11309267 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11309267 | pubmed:volume | 132 | lld:pubmed |
| pubmed-article:11309267 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11309267 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11309267 | pubmed:pagination | 1941-7 | lld:pubmed |
| pubmed-article:11309267 | pubmed:dateRevised | 2010-11-18 | lld:pubmed |
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| pubmed-article:11309267 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11309267 | pubmed:articleTitle | 5-HT(4) receptors mediating enhancement of contractility in canine stomach; an in vitro and in vivo study. | lld:pubmed |
| pubmed-article:11309267 | pubmed:affiliation | Department of Gastrointestinal Pharmacology, Janssen Research Foundation, Beerse Belgium. kprins@janbe.jnj.com | lld:pubmed |
| pubmed-article:11309267 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11309267 | pubmed:publicationType | In Vitro | lld:pubmed |
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