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pubmed-article:11308178pubmed:abstractTextIschemia/reperfusion injury can complicate recovery in cardiac operations. Ischemia induces endothelial dysfunction, which may contribute to leukocyte accumulation during reperfusion. Leukocyte-mediated injury may then occur. Using intravital microscopy we previously reported increased leukocyte retention in coronary capillaries and venules during early reperfusion during warm ischemia/reperfusion. In this study we investigated whether cold cardioplegic protection would limit leukocyte sequestration in coronary microvessels early in reperfusion. Pentoxifylline (PTX) has antiinflammatory effects and may limit endothelial dysfunction during ischemia/reperfusion. The effect of cardioplegia modification with PTX was also examined.lld:pubmed
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pubmed-article:11308178pubmed:authorpubmed-author:CopelandJ GJGlld:pubmed
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pubmed-article:11308178pubmed:dateRevised2007-11-14lld:pubmed
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pubmed-article:11308178pubmed:articleTitlePentoxifylline reduces coronary leukocyte accumulation early in reperfusion after cold ischemia.lld:pubmed
pubmed-article:11308178pubmed:affiliationSection of Cardiovascular and Thoracic Surgery and the Sarver Heart Center, Tucson, Arizona, USA.lld:pubmed
pubmed-article:11308178pubmed:publicationTypeJournal Articlelld:pubmed
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pubmed-article:11308178pubmed:publicationTypeResearch Support, U.S. Gov't, P.H.S.lld:pubmed
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