| pubmed-article:11294841 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C0908711 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C1179435 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C0079189 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C0110279 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C0086982 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C2003941 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C0205369 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C0205199 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C0376315 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C1705248 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C1548799 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C1524073 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C1514873 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C0449432 | lld:lifeskim |
| pubmed-article:11294841 | lifeskim:mentions | umls-concept:C0755506 | lld:lifeskim |
| pubmed-article:11294841 | pubmed:issue | 25 | lld:pubmed |
| pubmed-article:11294841 | pubmed:dateCreated | 2001-6-18 | lld:pubmed |
| pubmed-article:11294841 | pubmed:abstractText | Ciliary neurotrophic factor (CNTF) is a cytokine supporting the differentiation and survival of a number of neural cell types. Its receptor complex consists of a ligand-binding component, CNTF receptor (CNTFR), associated with two signaling receptor components, gp130 and leukemia inhibitory factor receptor (LIFR). Striking phenotypic differences between CNTF- and CNTFR-deficient mice suggest that CNTFR serves as a receptor for a second developmentally important ligand. We recently demonstrated that cardiotrophin-like cytokine (CLC) associates with the soluble orphan receptor cytokine-like factor-1 (CLF) to form a heterodimeric cytokine that displayed activities only on cells expressing the tripartite CNTF receptor on their surface. In this present study we examined the membrane binding of the CLC/CLF composite cytokine and observed a preferential interaction of the cytokine with the CNTFR subunit. Signaling pathways recruited by the CLC/CLF complex in human neuroblastoma cell lines were also analyzed in detail. The results obtained showed an activation of Janus kinases (JAK1, JAK2, and TYK2) leading to a tyrosine phosphorylation of the gp130 and LIFR. The phosphorylated signaling receptors served in turn as docking proteins for signal transducing molecules such as STAT3 and SHP-2. In vitro analysis revealed that the gp130-LIFR pathway could also stimulate the phosphatidylinositol 3-kinase and the mitogen-activated protein kinase pathways. In contrast to that reported before for CNTF, soluble CNTFR failed to promote the action CLC/CLF, and an absolute requirement of the membrane form of CNTFR was required to generate a functional response to the composite cytokine. This study reinforces the functional similarity between CNTF and the CLC/CLF composite cytokine defining the second ligand for CNTFR. | lld:pubmed |
| pubmed-article:11294841 | pubmed:language | eng | lld:pubmed |
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| pubmed-article:11294841 | pubmed:citationSubset | IM | lld:pubmed |
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| pubmed-article:11294841 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11294841 | pubmed:month | Jun | lld:pubmed |
| pubmed-article:11294841 | pubmed:issn | 0021-9258 | lld:pubmed |
| pubmed-article:11294841 | pubmed:author | pubmed-author:GuilletCC | lld:pubmed |
| pubmed-article:11294841 | pubmed:author | pubmed-author:ChevalierSS | lld:pubmed |
| pubmed-article:11294841 | pubmed:author | pubmed-author:GascanHH | lld:pubmed |
| pubmed-article:11294841 | pubmed:author | pubmed-author:GauchatJ FJF | lld:pubmed |
| pubmed-article:11294841 | pubmed:author | pubmed-author:LelièvreEE | lld:pubmed |
| pubmed-article:11294841 | pubmed:author | pubmed-author:FrogerJJ | lld:pubmed |
| pubmed-article:11294841 | pubmed:author | pubmed-author:ElsonG CGC | lld:pubmed |
| pubmed-article:11294841 | pubmed:author | pubmed-author:Plun-FavreauH... | lld:pubmed |
| pubmed-article:11294841 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11294841 | pubmed:day | 22 | lld:pubmed |
| pubmed-article:11294841 | pubmed:volume | 276 | lld:pubmed |
| pubmed-article:11294841 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11294841 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11294841 | pubmed:pagination | 22476-84 | lld:pubmed |
| pubmed-article:11294841 | pubmed:dateRevised | 2009-11-19 | lld:pubmed |
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| pubmed-article:11294841 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11294841 | pubmed:articleTitle | Signaling pathways recruited by the cardiotrophin-like cytokine/cytokine-like factor-1 composite cytokine: specific requirement of the membrane-bound form of ciliary neurotrophic factor receptor alpha component. | lld:pubmed |
| pubmed-article:11294841 | pubmed:affiliation | INSERM EMI-9928, CHU d'Angers, 4 rue Larrey, 49003 Angers, France and the Centre d'Immunologie Pierre Fabre, 5 avenue Napoléon III, 74164 Saint Julien en Genevois, France. | lld:pubmed |
| pubmed-article:11294841 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11294841 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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