| pubmed-article:11290802 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11290802 | lifeskim:mentions | umls-concept:C0002092 | lld:lifeskim |
| pubmed-article:11290802 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11290802 | lifeskim:mentions | umls-concept:C0458827 | lld:lifeskim |
| pubmed-article:11290802 | lifeskim:mentions | umls-concept:C0253486 | lld:lifeskim |
| pubmed-article:11290802 | lifeskim:mentions | umls-concept:C1704632 | lld:lifeskim |
| pubmed-article:11290802 | lifeskim:mentions | umls-concept:C0871261 | lld:lifeskim |
| pubmed-article:11290802 | lifeskim:mentions | umls-concept:C0011155 | lld:lifeskim |
| pubmed-article:11290802 | lifeskim:mentions | umls-concept:C2911692 | lld:lifeskim |
| pubmed-article:11290802 | lifeskim:mentions | umls-concept:C1706817 | lld:lifeskim |
| pubmed-article:11290802 | lifeskim:mentions | umls-concept:C0805586 | lld:lifeskim |
| pubmed-article:11290802 | lifeskim:mentions | umls-concept:C2349975 | lld:lifeskim |
| pubmed-article:11290802 | pubmed:issue | 8 | lld:pubmed |
| pubmed-article:11290802 | pubmed:dateCreated | 2001-4-6 | lld:pubmed |
| pubmed-article:11290802 | pubmed:abstractText | To evaluate the role of CCR2 in allergic asthma, mutant mice deficient in CCR2 (CCR2(-/-)) and intact mice were sensitized with i.p. OVA with alum on days 0 and 7, and challenged by inhalation with nebulization of either OVA or saline. Airway hyperreactivity, measured by the methacholine-provoked increase in enhanced pause, was significantly increased (p < 0.05) in OVA-challenged CCR2(-/-) mutant mice, compared with comparably challenged CCR2(+/+) mice. OVA-challenged CCR2(-/-) mutants also were also found to have enhanced bronchoalveolar lavage fluid eosinophilia, peribronchiolar cellular cuffing, and Ig subclass switching, with increase in OVA-specific IgG(1) and IgE. In addition, RNase protection assay revealed increased whole lung expression of IL-13 in OVA-challenged CCR2(-/-) mutants. Unexpectedly, serum monocyte chemotactic protein-1 levels were 8-fold higher in CCR2(-/-) mutants than in CCR2(+/+) mice sensitized to OVA, but OVA challenge had no additional effect on circulating monocyte chemotactic protein-1 in either genotype. Ag stimulation of lymphocytes isolated from OVA-sensitized CCR2 mutants revealed a significant increase (p < 0.05) in IL-5 production, which differed from OVA-stimulated lymphocytes from sensitized CCR2(+/+) mice. These experiments demonstrate an enhanced response in airway reactivity and in lung inflammation in CCR2(-/-) mutant mice compared with comparably sensitized and challenged CCR2(+/+) mice. These observations suggest that CC chemokines and their receptors are involved in immunomodulation of atopic asthma. | lld:pubmed |
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| pubmed-article:11290802 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11290802 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11290802 | pubmed:citationSubset | AIM | lld:pubmed |
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| pubmed-article:11290802 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11290802 | pubmed:month | Apr | lld:pubmed |
| pubmed-article:11290802 | pubmed:issn | 0022-1767 | lld:pubmed |
| pubmed-article:11290802 | pubmed:author | pubmed-author:KimYY | lld:pubmed |
| pubmed-article:11290802 | pubmed:author | pubmed-author:FeldmanSS | lld:pubmed |
| pubmed-article:11290802 | pubmed:author | pubmed-author:FuS MSM | lld:pubmed |
| pubmed-article:11290802 | pubmed:author | pubmed-author:SaksR GRG | lld:pubmed |
| pubmed-article:11290802 | pubmed:author | pubmed-author:KuzielW AWA | lld:pubmed |
| pubmed-article:11290802 | pubmed:author | pubmed-author:Sung Ss | lld:pubmed |
| pubmed-article:11290802 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11290802 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11290802 | pubmed:volume | 166 | lld:pubmed |
| pubmed-article:11290802 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11290802 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11290802 | pubmed:pagination | 5183-92 | lld:pubmed |
| pubmed-article:11290802 | pubmed:dateRevised | 2007-11-15 | lld:pubmed |
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| pubmed-article:11290802 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11290802 | pubmed:articleTitle | Enhanced airway Th2 response after allergen challenge in mice deficient in CC chemokine receptor-2 (CCR2). | lld:pubmed |
| pubmed-article:11290802 | pubmed:affiliation | Division of Pulmonary and Critical Care Medicine, and Division of Rheumatology and Immunology, University of Virginia Health System, Charlottesville, VA 22908, USA. | lld:pubmed |
| pubmed-article:11290802 | pubmed:publicationType | Journal Article | lld:pubmed |
| pubmed-article:11290802 | pubmed:publicationType | Research Support, U.S. Gov't, P.H.S. | lld:pubmed |
| pubmed-article:11290802 | pubmed:publicationType | Research Support, Non-U.S. Gov't | lld:pubmed |
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