| pubmed-article:11289103 | rdf:type | pubmed:Citation | lld:pubmed |
| pubmed-article:11289103 | lifeskim:mentions | umls-concept:C0026809 | lld:lifeskim |
| pubmed-article:11289103 | lifeskim:mentions | umls-concept:C1319315 | lld:lifeskim |
| pubmed-article:11289103 | lifeskim:mentions | umls-concept:C0021853 | lld:lifeskim |
| pubmed-article:11289103 | lifeskim:mentions | umls-concept:C0079419 | lld:lifeskim |
| pubmed-article:11289103 | lifeskim:mentions | umls-concept:C0087049 | lld:lifeskim |
| pubmed-article:11289103 | lifeskim:mentions | umls-concept:C1527148 | lld:lifeskim |
| pubmed-article:11289103 | lifeskim:mentions | umls-concept:C0205359 | lld:lifeskim |
| pubmed-article:11289103 | pubmed:issue | 6 | lld:pubmed |
| pubmed-article:11289103 | pubmed:dateCreated | 2001-4-5 | lld:pubmed |
| pubmed-article:11289103 | pubmed:abstractText | This study was conducted to confirm the hypothesis that intestinal microflora are required for the development of adenocarcinoma in the colon of the TCRbeta and p53 double-knockout (TCRbeta-/- p53-/-) mouse. Germ-free TCRbeta-/- p53-/- mice were produced. At 7 weeks of age, the animals were divided into two groups (n = 10/group), and one of these groups was conventionalized. Animals of both groups were subjected to histopathological examination for adenocarcinoma of the colon at 4 months of age. There was no development of adenocarcinoma of the colon among the germ-free mice, whereas in the conventionalized group, adenocarcinomas of the ileocecum and cecum were detected in 70% of animals. These results indicate the usefulness of the TCRbeta-/- p53-/- mouse as a colon cancer animal model that develops spontaneous adenocarcinoma of the colon early in life, and suggest that intestinal microflora play a major role in the development of adenocarcinoma of the colon in this animal model. | lld:pubmed |
| pubmed-article:11289103 | pubmed:language | eng | lld:pubmed |
| pubmed-article:11289103 | pubmed:journal | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11289103 | pubmed:citationSubset | IM | lld:pubmed |
| pubmed-article:11289103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11289103 | pubmed:chemical | http://linkedlifedata.com/r... | lld:pubmed |
| pubmed-article:11289103 | pubmed:status | MEDLINE | lld:pubmed |
| pubmed-article:11289103 | pubmed:month | Mar | lld:pubmed |
| pubmed-article:11289103 | pubmed:issn | 0008-5472 | lld:pubmed |
| pubmed-article:11289103 | pubmed:author | pubmed-author:UchidaKK | lld:pubmed |
| pubmed-article:11289103 | pubmed:author | pubmed-author:AndoMM | lld:pubmed |
| pubmed-article:11289103 | pubmed:author | pubmed-author:NagataYY | lld:pubmed |
| pubmed-article:11289103 | pubmed:author | pubmed-author:MatsuokaYY | lld:pubmed |
| pubmed-article:11289103 | pubmed:author | pubmed-author:MorotomiMM | lld:pubmed |
| pubmed-article:11289103 | pubmed:author | pubmed-author:IwataSS | lld:pubmed |
| pubmed-article:11289103 | pubmed:author | pubmed-author:OhwakiMM | lld:pubmed |
| pubmed-article:11289103 | pubmed:author | pubmed-author:OnoueMM | lld:pubmed |
| pubmed-article:11289103 | pubmed:author | pubmed-author:KadoSS | lld:pubmed |
| pubmed-article:11289103 | pubmed:author | pubmed-author:FunabashiHH | lld:pubmed |
| pubmed-article:11289103 | pubmed:issnType | Print | lld:pubmed |
| pubmed-article:11289103 | pubmed:day | 15 | lld:pubmed |
| pubmed-article:11289103 | pubmed:volume | 61 | lld:pubmed |
| pubmed-article:11289103 | pubmed:owner | NLM | lld:pubmed |
| pubmed-article:11289103 | pubmed:authorsComplete | Y | lld:pubmed |
| pubmed-article:11289103 | pubmed:pagination | 2395-8 | lld:pubmed |
| pubmed-article:11289103 | pubmed:dateRevised | 2005-11-17 | lld:pubmed |
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| pubmed-article:11289103 | pubmed:meshHeading | pubmed-meshheading:11289103... | lld:pubmed |
| pubmed-article:11289103 | pubmed:meshHeading | pubmed-meshheading:11289103... | lld:pubmed |
| pubmed-article:11289103 | pubmed:meshHeading | pubmed-meshheading:11289103... | lld:pubmed |
| pubmed-article:11289103 | pubmed:meshHeading | pubmed-meshheading:11289103... | lld:pubmed |
| pubmed-article:11289103 | pubmed:meshHeading | pubmed-meshheading:11289103... | lld:pubmed |
| pubmed-article:11289103 | pubmed:year | 2001 | lld:pubmed |
| pubmed-article:11289103 | pubmed:articleTitle | Intestinal microflora are necessary for development of spontaneous adenocarcinoma of the large intestine in T-cell receptor beta chain and p53 double-knockout mice. | lld:pubmed |
| pubmed-article:11289103 | pubmed:affiliation | Yakult Central Institute for Microbiological Research, Tokyo, Japan. shoichi-kado@yakult.co.jp | lld:pubmed |
| pubmed-article:11289103 | pubmed:publicationType | Journal Article | lld:pubmed |
| entrez-gene:21577 | entrezgene:pubmed | pubmed-article:11289103 | lld:entrezgene |
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